Polina Hogeweg ( Dutch. Paulien Hogeweg ; b. 1943 ) - Dutch theoretical biologist and researcher of complex systems . In 1970, along with Ben Hesper, she introduced the term bioinformatics [1] [2] , defining it as "the study of information processes in biotic systems."
| Pauline Hogeweg | |
|---|---|
| Paulien hogeweg | |
| Date of Birth | 1943 |
| Place of Birth | |
| A country | Netherlands |
| Scientific field | theoretical biology |
| Place of work | University of Utrecht |
| Alma mater | |
| Known as | coined the term bioinformatics in 1970 |
Education and career
Hogeveg received a bachelor's degree from the University of Amsterdam in 1969. In 1976, she received a Ph.D. Utrecht University ; Her doctoral dissertation is entitled “Topics in Biological Pattern Analysis” and relates to patterning and pattern recognition theory in biology. In 1977, Hogeveg founded the research group of the University of Utrecht on theoretical biology and bioinformatics and headed it until 2009.
Research
She was one of the pioneers of agent-based modeling of the study of the development of social structures in animal communities, using the principle of opportunity: “agents do what can be done in this situation” and the hierarchy principle, also known as the “winner and loser effect”. [3] She was one of the first to use cellular automata to study environmental and evolutionary processes and showed that the spatial formation of patterns can change the influence of the driving forces of evolution. [4] By expanding the Potts cell model to study morphogenesis and development, she was able to model the complete life cycle of Dictyostelium discoideum using simple rules for chemotaxis and differential adhesion. [5] This approach is now used for modeling in many areas of developmental biology (also evolutionary developmental biology , and for modeling the migration of immune cells of lymphoid tissue.
Notes
- ↑ Hesper B., Hogeweg P. (1970.) “Bioinformatica: een werkconcept”, Kameleon , 1 (6): 28–29.
- ↑ Hogeweg P. The roots of bioinformatics in theoretical biology. (English) // Public Library of Science for Computational Biology. - 2011 .-- Vol. 7, no. 3 . - P. e1002021. - DOI : 10.1371 / journal.pcbi.1002021 . - PMID 21483479 .
- ↑ Hogeweg, P. and B. Hesper (1985) Socioinformatic processes, a MIRROR modeling methodology. J Theor Biol 113: 311-330; Hogeweg, P. and B. Hesper (1983) The ontogeny of the interaction structure in bumblebee colonies: a MIRROR model ", Behav Ecol Sociobiol , 12: 271-283.
- ↑ Boerlijst MA and Hogeweg P. (1991) Spiral wave structure in pre-biotic evolution: Hypercycles stable against parasites. Physica D 48: 17-28; Hogeweg, P. and B. Hesper (1981a) Two predators and a prey in a patchy environment: An application of MICMAC modeling. J Theor Biol 93: 411-432.
- ↑ Maree AFM & Hogeweg P. (2001) How amoeboids self-organize into a fruiting body: Multicellular coordination in Dictyostelium discoideum. Proc Natl Acad Sci USA 98: 3879-3883; Savill, NJ and Hogeweg, P. (1997) Modeling morphogenesis: from single cells to crawling slugs. J Theor Biol 184: 229-235.