LGP2 (RIG-I-like receptor 3) is a receptor of the group of RIG-I-like receptors , a helicase enzyme . It is a regulator of two other receptors of the RIG-I and MDA5 group. Human gene product DHX58 .
| LGP2 | |
|---|---|
 LGP2 protein structure | |
| Designations | |
| Characters | LGP2 ; DHX58, D11LGP2, RLR-3 |
| Entrez gene | 79132 |
| Hgnc | 29517 |
| Omim | 608588 |
| Refseq | NM_024119 |
| Uniprot | Q96C10 |
| Other data | |
| Cipher cf | 3.6.4.13 |
| Locus | 17th ridge , 17q21.2 |
Content
Function
LGP2 is an intracellular pattern recognition receptor that is involved in the antiviral response of the innate immunity system of the body. LGP2 lacks the CARD domain, which is necessary for activation of the intracellular signal; therefore, the binding of the receptor to the viral ligand does not induce an antiviral cell response in itself. It is a regulator of two other receptors of the RIG-I and MDA5 group, and can both inhibit them and activate them. The effect may depend on the virus and cell type. Inhibition can occur due to competitive ligand binding, which reduces the amount of viral RNA available for RIG-I. Activation is possible due to the deployment of viral RNA or the removal of RNA-linked proteins, which facilitates the recognition of viral RNA by the RIG-I receptor.
LGP2 is involved in the immune response to viruses such as poxviruses , as well as the bacterial pathogen Listeria monocytogenes .
LGP2 recognizes single-stranded RNAs and double-stranded RNAs, with predominantly binding 5'-triphosphorylated double-stranded RNAs. [one]
See also
- RIG-I-like receptors
Notes
Literature
- Maruyama K., Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (English) // Gene: journal. - 1994. - Vol. 138 , no. 1-2 . - P. 171-174 . - DOI : 10.1016 / 0378-1119 (94) 90802-8 . - PMID 8125298 .
- Bonaldo MF, Lennon G., Soares MB Normalization and subtraction: two approaches to facilitate gene discovery. (Eng.) // Genome Research : journal. - 1997. - Vol. 6 , no. 9 . - P. 791-806 . - DOI : 10.1101 / gr . 6.9.791 . - PMID 8889548 .
- Suzuki Y., Yoshitomo-Nakagawa K., Maruyama K., et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. (English) // Gene: journal. - 1997. - Vol. 200 , no. 1-2 . - P. 149-156 . - DOI : 10.1016 / S0378-1119 (97) 00411-3 . - PMID 9373149 .
- Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2003. - Vol. 99 , no. 26 . - P. 16899-16903 . - DOI : 10.1073 / pnas.242603899 . - PMID 12477932 .
- Ota T., Suzuki Y., Nishikawa T., et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. (Eng.) // Nature Genetics : journal. - 2004. - Vol. 36 , no. 1 . - P. 40-5 . - DOI : 10.1038 / ng1285 . - PMID 14702039 .
- Rual JF, Venkatesan K., Hao T., et al. Towards a proteome-scale map of the human protein-protein interaction network. (English) // Nature: journal. - 2005. - Vol. 437 , no. 7062 . - P. 1173-1178 . - DOI : 10.1038 / nature04209 . - PMID 16189514 .
- Komuro A., Horvath CM RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. (English) // Journal of Virology : journal. - 2007. - Vol. 80 , no. 24 . - P. 12332-12342 . - DOI : 10.1128 / JVI.01325-06 . - PMID 17020950 .