Panavir - a substance of plant origin (extract from the shoots of tuberous nightshade ), called the original Russian antiviral drug. It is positioned by the manufacturer as a broad-spectrum antiviral agent. It is a plant polysaccharide belonging to the class of high molecular weight glycosides of complex structure. It consists of the following sugars ( hexoses ) - glucose , galactose , ramnose , mannose , xylose , arabinose, as well as uronic acids .
| Panavir | |
|---|---|
| Solanum tuberosum | |
| Active substance | |
| potato hexose glycoside | |
| Classification | |
| Farmakol. Group | Antivirals [1] |
| ATX | |
| Dosage Forms | |
| Solution for intravenous administration, rectal suppositories, vaginal suppositories, gel for external and local use | |
The grouping name assigned to the drug during registration [2] on the territory of the Russian Federation: "Potato shoot extract." When re-registering the drug in 2011, the grouping name was changed to: “ Solanum tuberosum shoot polysaccharides”. Panavir is also registered in Ukraine, Belarus [3] , Azerbaijan, Kazakhstan, Uzbekistan, Moldova and Georgia . No international nonproprietary name .
Content
- 1 mechanism of action
- 2 Development and production
- 3 Applications
- 3.1 Treatment
- 3.2 Prevention
- 4 Contraindications
- 5 notes
- 6 Literature
Mechanism of Action
Design and Production
Various forms of release
The developer and manufacturer of Panavir preparations is LLC National Research Company. The substance is not patented.
On the market, the drug is presented in several forms of release: intravenous solution, rectal , vaginal suppositories , gel and spray.
Applications
Treatment
According to the manufacturer's instructions, Panavir is indicated in the treatment of the following diseases:
- Herpes virus infections of various localization [4] [5] [6] [7] [8] [9] [10] (including recurrent genital herpes , herpes Zoster, and ophthalmic herpes).
- Secondary immunodeficiency conditions against the background of infectious diseases [11] [12] .
- Cytomegalovirus infection [13] [14] [15] , including in patients with habitual miscarriage. It is used in women with a chronic viral infection and interferon-deficient state in preparation for pregnancy.
- Human papillomavirus infection [4] [5] [6] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [33] [34] [35] [36] (anogenital warts) as part of complex therapy.
- Peptic ulcer of the stomach and duodenum [37] in patients with long-term scarring ulcers and symptomatic ulcers of the gastroduodenal zone as part of complex therapy.
- Tick-borne encephalitis [38] in order to reduce viral load and relieve neurological symptoms (anisoreflexia, decrease reflexes, soreness of exit points of cranial nerves, nystagmus) as part of complex therapy.
- Rheumatoid arthritis [39] , combined with herpes virus infection in immunocompromised patients (to enhance the analgesic and anti-inflammatory effect of the main therapy), as part of complex therapy.
- SARS and influenza as part of complex therapy [40] .
- Panavir is used in the treatment of chronic bacterial prostatitis . [41] [42]
Prevention
- Protection of the skin and mucous membranes from viral infections. It forms a protective coating, moisturizes and softens. [43]
Contraindications
The manufacturer claims the following contraindications to the drug, identified as a result of clinical trials:
- Individual intolerance. Panavir should not be used in patients with allergies to the components of the drug: glucose, mannose, ramnose, arabinose, xylose.
- Lactation period.
- Panavir vaginal suppositories should not be used for severe diseases of the kidneys and spleen, during pregnancy and lactation.
- Children's age up to 12 years.
Notes
- ↑ Polysaccharides of Solanum tuberosum shoots: instructions, use and formula . Encyclopedia of medicines and pharmaceutical products . Date of appeal September 27, 2013.
- ↑ State register of medicines
- ↑ State Register of Medicines of the Republic of Belarus (Unavailable link) . Date of treatment May 25, 2019. Archived October 14, 2013.
- ↑ 1 2 Kucherov V. A., Stovbun S. V., Safronov D.Yu. - New approaches in the treatment of recurrent genital herpetic infection associated with human papillomavirus infection. // “Problems of reproduction”, No. 6/2011
- ↑ 1 2 A.V. Zuev, N.V., Shperling A.A., Sharopina, E.A. Kruk, A.A. Gontar. - The rationale for the use and effectiveness of Panavir in patients with various types of genital herpes simplex course. // Clinical Dermatology and Venereology, No. 6, 2012
- ↑ 1 2 Yu. Perlamutrov, N. Chernova, S. Stovbun, V. Kucherov - Therapy of recurrent genital herpetic infection. // Magazine "Doctor" No. 8 of 2010, S. 50-51
- ↑ A. V. Zuev, V. S. Dmitruk, M. A. Yakunina, A. N. Likhachevskaya, S. V. Stovbun, V. A. Kucherov, V. L. Chekameeva - Experience with Panavir in a patient with a deep bubble form of HERPES ZOSTER // Experimental and Clinical Dermatocosmetology No. 2, 2011. - p. 39-42
- ↑ Moiseenko O. M., Balabina O. V. Efficacy of the antiviral drug Panavir in the complex treatment of recurrent ophthalmic herpes. // New in ophthalmology, 4/2004 p.50-51
- ↑ Kuzovkova T.V., Gerasimova N.M., Kungurov N.V., Evstigneeva N.P., Chigvintseva E.A. - Therapy and prevention of relapse in severe genital herpes virus infections. // Clinical Dermatology and Venereology, No. 2.2005
- ↑ Yu. Perlamutrov, N. Chernova, E. Naletova Recurrent genital herpetic infection: optimization of therapy // Journal “Doctor” No. 01.01.2010 p.64-65
- ↑ E. A. Batkaev, D. V. Ryumin, I. E. Drozdova, V. A. Kucherov - A differentiated approach to immunotherapy in the complex treatment of genital papillomavirus infection. // Journal "Bulletin of postgraduate medical education" No. 2, 2010, S. 72-74
- ↑ A. V. Molochkov, G. E. Bagramova, M. A. Gureeva, A. N. Khlebnikova, Kucherov V. A., Stovbun S. V., Safronov D.Yu. - Immunotropic and antiviral therapy of skin tumors associated with papillomavirus infection. // Clinical Dermatology and Venereology, No. 2 2012
- ↑ Karakhalis L. Yu., Kucherov V.A., Stovbun S.V., Safronov D. Yu. - Evaluation of the effectiveness of using various forms of the “PANAVIR” drug in patients of reproductive age with cytomegalovirus infection. // Russian Bulletin of the Obstetrician-Gynecologist, No. 5
- ↑ Chernova N. I. - Features of the course of cytomegalovirus infection of the urogenital tract in sexually active women. // Clinical Dermatology and Venereology, No. 6, 2012
- ↑ Mother of Pearl Yu., Chernova N. - Therapy of patients with genital cytomegalovirus infection. // Doctor, 06.2010
- ↑ E. A. Batkaev, D. V. Ryumin, I. E. Drozdova, V. A. Kucherov - A differentiated approach to immunotherapy in the complex treatment of genital papillomavirus infection. // Journal "Bulletin of postgraduate medical education" No. 2, 2010, S. 72-74
- ↑ Reva N. L., Kucherov V. A., Stovbun S. V., Safronov D. Yu. - Treatment of chronic cervicitis associated with the human papillomavirus in pregnant women. // "Journal of Obstetrics and Women's Diseases" No. 2, 2011
- ↑ Klyucherova S.V., Stovbun S.V., Safronov D. Yu., Kucherov V.A., Farzaliev T.N. - A modern view of the problem of tactics of anti-relapse therapy of associated viral infections in anogenital warts. // "Reviews on clinical pharmacology and drug therapy" No. 2, 2011
- ↑ N.I. Chernova. Kucherov V. A., Stovbun S. V., Safronov D. Yu., Litvin A. A. - Differentiated management of patients with recurrent genital papillomavirus infection. // Clinical Dermatology and Venereology No. 3, 2011
- ↑ Perlamutrov Yu. N., Chernova N. I. - Ways to increase the effectiveness of complex therapy with antiviral drugs for human papillomavirus infection // Clinical Dermatology and Venereology, No. 5
- ↑ Stovbun S.V., Safronov D. Yu., Kucherov V.A., Farzaliev T.N. - Modern possibilities of complex therapy in the treatment of subclinical and clinical forms of PVI. // Clinical Dermatology and Venereology, No. 4
- ↑ Kononova I.N .; Ivanova I.P. Kucherov V.A., Stovbun S.V., Safronov D. Yu. - Algorithm for examination and management of women with genital lesions of human papilloma virus of high oncogenic risk. // Russian Bulletin of the Obstetrician-Gynecologist, No. 6
- ↑ Pearl pearls Yu. N., Chernova N.I., Kucherov V.A., Stovbun S.V., Safronov D. Yu. - Ways to increase the effectiveness of therapy for papillomavirus infection // Clinical Dermatology and Venereology, No. 5
- ↑ T. A. Oboskalova, I. N. Kononova, V. A. Kucherov, S. V. Stovbun, D. Yu. Safronov - The effectiveness of complex therapy in patients with HPV-associated chronic cervicitis. // “Problems of reproduction”, No. 5/2011
- ↑ Maltseva L.I., Farrakhova L.N., Kucherov V.A., Stovbun S.V. - Genital warts in women. // Russian Bulletin of the Obstetrician-Gynecologist, No. 2
- ↑ Ayvazova D.S., Palchik E.A., Duyanova O.P., Kucherov V.A., Stovbun S.V. - Therapy of dystrophic changes in the vulva in perimenopausal women with the Panavir gel. // Russian Bulletin of the Obstetrician-Gynecologist, No. 6
- ↑ Pearl mothers Yu. N., Chernova N.I., Kucherov V.A., Stovbun S.V. - Efficacy of a local action drug in the complex treatment of human papillomavirus infection. // Clinical Dermatology and Venereology, No. 3 2012
- ↑ A. V. Molochkov, G. E. Bagramova, M. A. Gureeva, A. N. Khlebnikova, Kucherov V. A., Stovbun S. V., Safronov D.Yu. - Immunotropic and antiviral therapy of skin tumors associated with papillomavirus infection. // Clinical Dermatology and Venereology, No. 2 2012
- ↑ G. E. Bagramova, M. A. Gureev, A. N. Khlebnikov, A. V. Molochkov. - Comprehensive treatment of genital papillomavirus infection. // Clinical Dermatology and Venereology, No. 4, 2012
- ↑ Prilepskaya V.N., Bebneva T.N., Shilyaev A. Yu., Tagieva A., Kucherov V.A., Stovbun S.V., Safronov D. Yu. - Cervical leukoplakia associated with HPV infection . // Russian Bulletin of the Obstetrician-Gynecologist, No. 4, 2012
- ↑ Karakhalis L. Yu., Zueva T. P., Petrenko S. I., Kucherov V. A., Stovbun S. V., Safronov D. Yu. - Optimization of treatment of cervical dysplasia associated with HPV infection. // Russian Bulletin of the Obstetrician-Gynecologist, No. 5 2012
- ↑ Prilepskaya V.N., Dovletkhanova E.R. - A modern look at the possibilities of treating HPV-associated genital diseases in women. // Gynecology, No. 6 (volume 14/2012)
- ↑ Oboskalova T.A., Kononova I.N., Voroshilina E.S., Kuzina T.V., Kucherov V.A., Stovbun S.V., Safronov D. Yu. - The effectiveness of antiviral therapy in the complex treatment of patients with HPV -associated cervical neoplasia. // Russian Bulletin of the Obstetrician-Gynecologist, No. 1 2013
- ↑ Perlamutrov Yu. N., Chernova N.I. - Modern approaches in the treatment of patients with genital papillomavirus infection. // Remedium p. 32-34, May 2010
- ↑ Kuznetsova Yu.N., Evstigneeva N.P., Oboskalova T.A. - Combined therapy of manifest manifestations of papilloma-virus infection of the urogenital tract. // Modern problems of dermatovenereology, immunology and medical cosmetology, No. 03 (06) 2009 p.27-31
- ↑ Baktaev E.A., Ryumin D.V., Drozdova I.S., Kucherov V.A. - Differentiated approach to immunotherapy in the complex treatment of human papillomavirus infection of genitalia. // Bulletin of postgraduate medical education, No. 2, 2010., p. 72-74
- ↑ Official clinical study “The efficacy and tolerability of Panavir in the form of monotherapy for peptic ulcer of the stomach and duodenum in the exacerbation phase associated with Helicobacter pulori,” Central Research Institute of Gastroenterology. - Doctor of Medicine, Professor, Vasiliev Yu.V., Doctor of Medicine Kastyanenko V.I.
- ↑ The official clinical study "On the clinical study of the effectiveness of the use of the drug Panavir for the treatment of virus carriage in tick-borne encephalitis" - MD, professor A.V. Lepekhin, N.P. Chernysheva, candidate of medical sciences, associate professor L.V. Lukashova, 2008
- ↑ I. Khripunova, A. Khripunova, S. Mnatsakanyan, S. Stovbun - Experience with the use of antiviral drugs in the treatment of reactive arthritis // Journal "Doctor" No. 8, 2010, P.67-70
- ↑ Official clinical trial “An open, controlled, randomized clinical trial evaluating the effectiveness and safety of Panavir solution for intravenous administration of 0.04 mg / ml in 5 ml ampoules in the treatment of acute respiratory viral infections and influenza” - Professor Ratnikova L.I., Dubovikova T.A. , Stenko E.A.
- ↑ Novikov A.I., Zaezhalkin V.V., Frolov S. Yu., Kucherov V.A. - Immunocorrecting therapy of chronic bacterial prostatitis // Abstracts. IV All-Russian Scientific and Practical Conference with International Participation "Rational Pharmacotherapy in Urology 2010", February 11-12, 2010, pp. 88-90
- ↑ A. I. Novikov, V. V. Zaezhalkin, V. A. Kucherov, S. Yu. Frolov - Evaluation of the effectiveness of Panavir in the complex treatment of patients with chronic bacterial prostatitis. // Journal "Effective Pharmacotherapy in Urology" No. 1, January 2010, pp. 12-14 Novikov A.I., Zaezhalkin V.V., Kucherov V.A., Frolov S. Yu. - Immunocorrecting therapy of chronic bacterial prostatitis // Journal "Urology" No. 4 of 2010, S. 44-48
- ↑ Gomberg M.A. Stovbun S.V., Kucherov V.A., Safronov D.Yu., Farzaliev T.N. - Is it possible to prevent transmission of the human papillomavirus in discordant pairs? // Practical medicine, No. 2 2011
Literature
- Gerasimchuk E.V. Experience in the use of panavir for herpesvirus and papillomavirus infections // Clinical Dermatology and Venereology. - 2006. - No. 4 . - S. 77-80 .
- Masyukova S. A., Kozhushkov A. I., Gladko O. V., Omarova M. A., Pospelova O. L., Stovbun S. V. Clinical study of the effectiveness of the drug Panavir in the treatment of recurrent genital herpes // Bulletin of Postgraduate Medical education. - 2002 .-- T. 4 . - S. 14-16 .
- Kungurov N.V., Gerasimova N.M., Kuznetsova Yu.N. et al. Clinical efficacy of Panavir in the treatment of papillomavirus infection // Clinical Dermatology and Venereology. - 2006. - No. 1 . - S. 24-26 .