The term “ physiome ” is now commonly used to denote a physiological description of the state of an individual individual or an “average representative” of a biological species, or its functional behavior. The Physiome describes the physiological dynamics of a normal healthy organism based on information about its structure ( genome , proteome , and morphome). The term comes from "physio-" (nature) and "-ome" (in general).
In the broadest sense, this term should define relations at different levels of organization of a biological being: from the genome to the whole organism and from functional behavior in the regulation of genes. As part of the IUPS Physiome project, it includes integrated models of components of organisms, such as individual organs or cell systems, biochemical, or endocrine systems.
Literature
- Crampin EJ , Halstead M. , Hunter P. , Nielsen P. , Noble D. , Smith N. , Tawhai M. Computational physiology and the physiome project (Eng.) // Exp. Physiol. : Journal. - 2004. - Vol. 89 , no. 1 . - P. 1-26 . - ISSN 0958-0670 . - DOI : 10.1113 / expphysiol.2003.026740 . - PMID 15109205 .
- Hunter, Peter J. , Thomas K. Borg. Integration from proteins to organs: the Physiome Project (Eng.) // Nature reviews. Molecular cell biology: journal. - 2001. - Vol. 4 , no. 3 . - P. 237-243 . - DOI : 10.1038 / nrm1054. . - PMID 12612642 .
Links
- Physiom project of the International Union of Physiological Sciences (IUPS)
- NSR Physiom Project of the National Resource Modeling Faculty of Bioengineering at the University of Washington
- STEP: Strategy of the European Physiom Project
- Invitation to the public Physiom project of the heart
- National Resource for Cellular Analysis and Modeling (NRCAM)
Physiome Project Examples