Herpesvirus thymidine kinase is a protein from the thymidine kinase family . [2]
| Herpesvirus Thymidine Kinase | |
|---|---|
 The structure of the herpes virus thymidine kinase. [one] | |
| Identifiers | |
| Symbol | Herpes_TK |
| Pfam | PF00693 |
| Interpro | IPR001889 |
| SCOP | 1kin |
| SUPERFAMILY | 1kin |
| Available protein structures | |
| Pfam | the structure |
| PDB | RCSB PDB ; PDBe ; PDBj |
| PDBsum | 3D model |
The presence of thymidine kinase in cells infected with herpes viruses activates many antiviral drugs against herpes and therefore these drugs only work in infected cells.
Herpesvirus thymidine kinase-activated antiviral drugs:
- Guanine purine analogues: acyclovir , famciclovir , ganciclovir , penciclovir , valaciclovir , valganciclovir
- vidarabine
- Pyrimidine analogues of uridine : idoxuridine , trifluridine
- brivudine
Notes
- ↑ Champness JN, Bennett MS, Wien F., et al. Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands // Proteins: journal. - 1998 .-- August ( vol. 32 , no. 3 ). - P. 350—361 . - DOI : 10.1002 / (SICI) 1097-0134 (19980815) 32: 3 <350 :: AID-PROT10> 3.0.CO; 2-8 . - PMID 9715911 .
- ↑ Brown DG, Visse R., Sandhu G., Davies A., Rizkallah PJ, Melitz C., Summers WC, Sanderson MR Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir ) // Nat. Struct. Biol. : journal. - 1995 .-- October ( vol. 2 , no. 10 ). - P. 876-881 . - DOI : 10.1038 / nsb1095-876 . - PMID 7552712 .