Methusol

Methusol
Methusol
	Mafusol
Composition
	sodium fumarate - electrolyte , antioxidant; sodium chloride - electrolyte; potassium chloride - electrolyte; magnesium chloride - electrolyte;
Classification
Farmakol. Group	Regulators of water-electrolyte balance and KShchS; Substitutes for plasma and other blood components
ATX
Dosage Forms
	400 ml solution for intravenous infusion

Methusol is a blood substitute developed by the Russian Research Institute of Hematology and Transfusiology .

It has a rehydrating, antioxidant , diuretic and detoxifying effect. Replenishes the volume of circulating blood in hypovolemic conditions, reduces blood viscosity and improves its rheological properties.

Content

Indications

Hypovolemic and hypoxic conditions of various etiologies ( blood loss , shock , trauma , intoxication ). Acute cerebrovascular accident ( stroke ), proceeding according to the ischemic and hemorrhagic type. As a component of the perfusion system for filling the heart-lung machine .

Contraindications

In all cases where intravenous administration of large volumes is contraindicated.

Drug Interactions

Methusol can be used in combination with colloidal solutions ( polyglyukin , reopoliglyukin , neogemodez , hemodez , gelatin, etc.); the drug is also compatible with donated blood, erythromass, plasma and other blood products.

The use of Methusol does not interfere with the use of commonly used antishock agents, including benzodiazepine drugs, as well as muscle relaxants (suxamethonium, etc.), proteolysis inhibitors ( aprotinin ) and adrenomimetics ( dopamine , adrenaline

Production

Manufactured by Medpolymer Firm OJSC (St. Petersburg) ^[1]

Notes

↑ ¹ ² Registration certificate (neopr.) . State register of medicines. Date of treatment February 22, 2013. Archived March 16, 2013.

Literature

Selivanov E. A., Slepneva L. V., Alekseeva N. N. et al. Fumarate-containing infusion solutions as a means of choice in emergency medical care (inaccessible link) . // Medicine of extreme situations. - M. , 2012 .-- No. 1 (39). - S. 85-94.
Selivanov E. A., Slepneva L. V., Alekseeva N. N., et al. Effectiveness of the use of fumarate-containing preparations of multifunctional action in the infusion therapy of emergency conditions . // Bulletin of St. Petersburg State Medical Academy. I.I. Mechnikov. - SPb. , 2006. - No. 2 (7). - S. 150-153.
Sofronov G. A., Selivanov E. A., Khanevich M. D. et al. Use of antihypoxic infusion solutions in surgery . // Bulletin of the National Medical and Surgical Center. N.I. Pirogova. - 2011. - T. 6. - No. 1, - S. 87-91. - ISSN 2072-8255

[regmed-1] ¹ ² Registration certificate (neopr.) . State register of medicines. Date of treatment February 22, 2013. Archived March 16, 2013.