AIM2 (from English absent in melanoma 2 ) is a protein that is involved in the regulation of the immune response. Human gene product AIM2 . [1] [2]
| AIM2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||
| Identifiers | |||||||||||||
| , PYHIN4, absent in melanoma 2 | |||||||||||||
| External IDs | |||||||||||||
| |||||||||||||
| RNA expression profile | |||||||||||||
 | |||||||||||||
| Ortologists | |||||||||||||
| Kinds | Person | Mouse | |||||||||||
| Entrez | |||||||||||||
| Ensembl | |||||||||||||
| UniProt | |||||||||||||
| RefSeq (mRNA) | |||||||||||||
| RefSeq (protein) | |||||||||||||
| Locus (UCSC) | |||||||||||||
| PubMed Search | |||||||||||||
| Wikidans | |||||||||||||
| View / Edit (Man) | View / Edit (Mouse) | ||||||||||||
Protein is a special type of inflamos that recognize foreign bacterial or viral DNA . [3]
Content
Functions
The protein is part of the Ifi202 / IFI16 cytokine family containing the HIN-200 domain. AIM2 expression is induced by interferon-gamma. [2]
AIM2 is capable of forming a special type of inflammasome , also called DNA inflammasomes for their ability to recognize foreign DNA due to the HIN200 domain that binds DNA, and the PYD domain that recruits the adapter protein ASC , necessary for the formation of inflammasomes. The complex is oligomerized in the presence of bacterial or viral DNA, as well as its own damaged DNA. The latter results in an autoimmune reaction. ASC contains the CARD domain ( English caspase activation and recruitment domain ), which, in turn, recruits pro- caspase-1, which leads to self-activation of caspase-1. Activated caspase-1 processes intelekin-1 beta and interleukin-18 inflammatory cytokines into active form. [3]
Structure
Protein AIM2 consists of 343 amino acids . Contains the N-terminal pyrin domain DAPIN (section 1-87) and the C-terminal HIN-200 domain (section 138-337), which includes 2 fragments capable of binding oligonucleotides. [four]
Clinical value
An increased level of AIM2 protein is found in the skin of patients with psoriasis . [five]
Notes
- Y DeYoung KL, Ray ME, Su YA, Anzick SL, Johnstone RW, JA Trapani, Meltzer PS, Trent JM Cloning and the melanoma (English). ) // Oncogene : journal. - 1997. - August ( vol. 15 , no. 4 ). P. 453–457 . - DOI : 10.1038 / sj.onc.1201206 . - PMID 9242382 .
- 2 1 2 Entrez Gene: AIM2 absent in melanoma 2 .
- ↑ 1 2 Schroder K., Tschopp J. The inflammasomes (Eng.) // Cell . - Cell Press , 2010. - March ( vol. 140 , no. 6 ). - P. 821-832 . - DOI : 10.1016 / j.cell.2010.01.040 . - PMID 20303873 .
- ↑ Fernandes-Alnemri T., Yu.W.W., Datta P., Wu J., Alnemri ES AIM2 activates the response to cytoplasmic DNA (Eng.) // Nature: journal. - 2009. - March ( vol. 458 , no. 7237 ). - P. 509-513 . - DOI : 10.1038 / nature07710 . - PMID 19158676 .
- ↑ Dombrowski, Y; Peric, M., Koglin, S., Kammerbauer, C., Göß, C., Anz, D., Simanski, M., Gläser, R., Harder, J., Hornung, V., Gallo, RL, Ruzicka , T., Besch, R., Schauber, J. Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions (eng.) // Science translational medicine: journal. - 2011. - 11 May ( vol. 3 , no. 82 ). - P. 82ra38-82ra38 . - DOI : 10.1126 / scitranslmed.3002001 . - PMID 21562230 .
Literature
- Landolfo S., Gariglio M., Gribaudo G., Lembo D. The Ifi 200 genes: an emerging family of IFN-inducible genes (eng.) // Biochimie : journal. - 1999. - Vol. 80 , no. 8-9 . - P. 721-728 . - DOI : 10.1016 / S0300-9084 (99) 80025-X . - PMID 9865494 .
- Woerner SM; Kloor M; Schwitalle Y; Youmans, Hanni; Doeberitz, Magnus von Knebel; Gebert, Johannes; Dihlmann, Susanne. The putative tumor suppressor AIM2 is frequently affected by microsatellite unstable colon cancers (Eng.) // Genes Chromosomes Cancer : journal. - 2007. - Vol. 46 , no. 12 - pp . 1080-1089 . - DOI : 10.1002 / gcc.20493 . - PMID 17726700 .
- Gregory SG; Barlow KF; McLay KE; Kaul, R .; Swarbreck, D .; Dunham, A .; Scott, CE; Howe, KL; Woodfine, K. The DNA sequence of human chromosome 1 (Eng.) // Nature: journal. - 2006. - Vol. 441 , no. 7091 . - P. 315–321 . - DOI : 10.1038 / nature04727 . - PMID 16710414 .
- Chen IF; Ou-Yang F; Hung JY; Liu, JC; Wang, H; Wang, SC; Hou, MF; Hortobagyi, GN; Hung, MC AIM2 suppressors in vitro and mammary tumor growth in a mouse model (English) // Mol. Cancer Ther. : journal. - 2006. - Vol. 5 , no. 1 . - P. 1-7 . - DOI : 10.1158 / 1535-7163.MCT-05-0310 . - PMID 16432157 .
- Cresswell KS; Clarke CJ; Jackson JT; Darcy, Phillip K .; Trapani, Joseph A .; Johnstone, Ricky W. Biochemical, AIM2, family member and putative tumor suppressor protein, // Biochem. Biophys. Res. Commun. : journal. - 2005. - Vol. 326 , no. 2 - P. 417-424 . - DOI : 10.1016 / j.bbrc.2004.11.048 . - PMID 15582594 .
- Liu G; Yu JS; Zeng G; Yin, Dong; Xie, Dong; Black, Keith L .; Ying, Han. AIM-2: a glioma cells (English) // J. Immunother. : journal. - 2004. - Vol. 27 , no. 3 - P. 220-226 . - DOI : 10.1097 / 00002371-200405000-00006 . - PMID 15076139 .
- Strausberg RL; Feingold EA; Grouse lh; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM; Schuler, GD Generation and the cDNA sequences (English) // Proceedings of the United States of America : journal. - 2003. - Vol. 99 , no. 26 - P. 16899-16903 . - DOI : 10.1073 / pnas.242603899 . - PMID 12477932 .
- Choubey, D., Walter, S., Geng, Y., X. H. Cyanoplastic, i.e., the 200-gene family ( IGN ) // FEBS Lett. : journal. - 2000. - Vol. 474 , no. 1 . - p . 38-42 . - DOI : 10.1016 / S0014-5793 (00) 01571-4 . - PMID 10828447 .