Kinetosome , or basal body , or basal granules , or blepharoplast - the organelle of a eukaryotic cell, a cylindrical structure of microtubules located at the base of undulipodia - flagella and cilia [1] . Being one of the types of microtubule organization centers (CTOMs), kinetosomes are formed from centrioles and serve as the basis for the formation of the flagella axoneme [1] .
Structure
The kinetosome consists of nine triplets of microtubules consisting of γ-tubulin and connected by dynein handles [1] . Two microtubules of each triplet directly pass into axoneme doublets [1] . The nucleotide-binding domain of γ-tubulin plays a key role in the formation and spatial organization of microtubules in the kinetosome [2] . Often, kinetosomes are anchored in the cytoplasm using the radicular apparatus, consisting of microtubules or transversely striated fibrillar roots [1] .
Notes
- ↑ 1 2 3 4 5 Ruppert E.E., Fox R.S., Barnes R.D. Protists and lower multicellular // Invertebrate Zoology. Functional and Evolutionary Aspects = Invertebrate Zoology: A Functional Evolutionary Approach / Per. from English T. A. Ganf, N. V. Lentsman, E. V. Sabaneeva; under the editorship of A. A. Dobrovolsky and A. I. Granovich. - 7th edition. - M .: Academy, 2008. - T. 1. - P. 31—34. - 496 p. - 3000 copies. - ISBN 978-5-7695-3493-5 .
- ↑ Shang, Y., Tsao, C.-C., Gorovsky, MA (2005). Mutational analyses reveal a novel function of the nucleotide-binding domain of gamma-tubulin in the regulation of basal body biogenesis. Journal of Cell Biology 171 (6): 1035-1044.