Syndecan 3 ( born syndecan 3 ) is a membrane protein , proteoglycan of the syndecan family, or transmembrane heparan sulfate proteoglycans. Human gene product SDC3 . Carries heparan sulfate chains on the surface.
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| Symbol | ; SDCN; SYND3 | ||||||||||||
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Content
- 1 Functions
- 2 Structure
- 3 Tissue specificity
- 4 See also
- 5 notes
- 6 Literature
- 7 References
Functions
The protein is a transmembrane heparan sulfate proteoglycan, part of the syndecan family. Sydecans mediate cell binding, signal transmission in the cell, and cytoskeletal organization. They are receptors for Tat protein of the HIV virus. Sindecan 3 may contain heparan sulfate chains. It plays a role in organizing the shape of the cell, acting on the actin cytoskeleton. Perhaps involved in the transmission of a signal from the cell surface mediated by oligosugars.
Structure
Mature protein consists of 442 amino acids, the molecular weight of the protein part is 45.5 kDa. It includes the N-terminal extracellular domain (387 amino acids), a single helical transmembrane fragment, and a small cytosolic region with one phosphorylated tyrosine . On the extracellular domain, there are up to 6 sites for the attachment of O- hepatransulfate chains.
Tissue specificity
Sindecan 3 is expressed in the nervous system, adrenal glands and spleen.
See also
- Syndecans
- Sindecan 1
- Sindecan 2
Notes
Literature
- Tyagi M., Rusnati M., Presta M., Giacca M. Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. (English) // J. Biol. Chem. : journal. - 2001. - Vol. 276 , no. 5 . - P. 3254-3261 . - DOI : 10.1074 / jbc.M006701200 . - PMID 11024024 .
- Koroll M., Rathjen FG, Volkmer H. The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity. (English) // J. Biol. Chem. : journal. - 2001. - Vol. 276 , no. 14 . - P. 10646-10654 . - DOI : 10.1074 / jbc.M010647200 . - PMID 11152476 .
- Hakansson S., Jacobs A., Caffrey M. Heparin binding by the HIV-1 tat protein transduction domain. (Eng.) // Protein Sci. : journal. - 2001. - Vol. 10 , no. 10 . - P. 2138-2139 . - DOI : 10.1110 / ps.23401 . - PMID 11567105 .
- Erdman R., Stahl RC, Rothblum K., et al. Schwann cell adhesion to a novel heparan sulfate binding site in the N-terminal domain of alpha 4 type V collagen is mediated by syndecan-3. (English) // J. Biol. Chem. : journal. - 2002. - Vol. 277 , no. 9 . - P. 7619—7625 . - DOI : 10.1074 / jbc.M111311200 . - PMID 11751872 .
- Alvarez K., Fadic R., Brandan E. Augmented synthesis and differential localization of heparan sulfate proteoglycans in Duchenne muscular dystrophy. (English) // J. Cell. Biochem. : journal. - 2002. - Vol. 85 , no. 4 . - P. 703-713 . - DOI : 10.1002 / jcb.10184 . - PMID 11968010 .
- Pacifici M., Shimo T., Gentili C., et al. Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis (Eng.) // J. Bone Miner. Metab. : journal. - 2005. - Vol. 23 , no. 3 . - P. 191-199 . - DOI : 10.1007 / s00774-004-0584-1 . - PMID 15838620 .
- Reizes O., Clegg DJ, Strader AD, Benoit SC A role for syndecan-3 in the melanocortin regulation of energy balance // Peptides: journal. - 2006 .-- February ( vol. 27 , no. 2 ). - P. 274-280 . - DOI : 10.1016 / j.peptides.2005.02.030 . - PMID 16289473 .