Brian Kobilka ( born May 30, 1955 , Little Falls , Minnesota ) - American crystallographer , Nobel Laureate in Chemistry for 2012 (with Robert Lefkowitz ) - "for research on receptors associated with G-proteins " [2] . Member of the US National Academy of Sciences (2011) [3] , MD, professor at Stanford.
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| Awards and prizes | Nobel Prize in Chemistry ( 2012 ) [d] [d] ( 2015 ) [d] ( 2016 ) |
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Biography
Born in the town of Little Falls . He graduated from the Minnesota, where he received a bachelor's degree. Then he graduated with honors from the Yale University . After completing his residency (analogous to residency) at the University of Washington Medical School in St. Louis, he got a job as a researcher under the supervision of Robert Lefkowitz at Duke University . Cloned β 2 -adrenergic receptors there . In 1989 he moved to Stanford [4] . In 1987-2003, a researcher at Howard Hughes Medical Institute [5] .
The fame brought to Brian Kobilka by the study of the structure and functionality of receptors associated with the G-protein . In particular, the Kobilka group was able to determine the molecular structure of β 2 -adrenergic receptors [6] [7] [8] [9] .
In 2016, he signed a letter calling on Greenpeace , the United Nations, and governments around the world to stop fighting genetically modified organisms ( GMOs ) [10] [11] [12] .
In 1994, Kobilka received the John Abel Pharmacology Award [13] . In 2007, Science magazine designated his study of the structure of GPCR receptors as the second most important scientific breakthrough of the year [14] .
- Pharmacology Krebs Lecture, University of Washington (2010)
- Earl and Thressa Stadtman Distinguished Scientist Award (2013)
Family
His grandfather - Felix Kobilka (1893-1991) and his father - Franklin Kobilka (1921-2004), as he himself were born in the town of Little Falls and worked in a bakery [15] [16] [17] . His grandmother, Isabella Susan Kobilka (nee Bear, 1891-1980), came from the Prussian families Bear and Kivel, who, since 1888, ran the historic Kiewel Brewery Brewery in Little Falls [18] . Brian's mother is Betty Kobilka (nee Faust, born 1930).
With his wife, Tong Sun Thian , he met at the University of Duluth. They have two children [19] .
Notes
- ↑ Encyclopædia Britannica
- ↑ The Nobel Prize in Chemistry 2012 . Nobel Media Date of treatment October 10, 2012. Archived October 16, 2012.
- ↑ Brian K. Kobilka
- ↑ The state of GPCR research in 2004: Nature Reviews Drug Discovery . Date of treatment October 16, 2008. Archived December 13, 2012.
- ↑ Brian K. Kobilka, MD . HHMI. Date of treatment August 24, 2012. Archived December 13, 2012.
- ↑ Forbes : Cell Insights Could Bring Better Drugs (Link unavailable - history ) . Date of treatment October 16, 2008.
- ↑ Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M., Ratnala VR, Sanishvili R., Fischetti RF, Schertler GF, Weis WI, Kobilka BK Crystal structure of the human β 2 -adrenergic G-protein-coupled receptor (Eng.) // Nature: journal. - 2007. - Vol. 450 , no. 7168 . - P. 383–387 . - DOI : 10.1038 / nature06325 . - PMID 17952055 .
- ↑ Cherezov V., Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P., Weis WI, Kobilka BK, Stevens RC High Resolution Crystal Structure of an Engineered Human β2-Adrenergic G protein-Coupled Receptor (Eng.) // Science: journal. - 2007. - Vol. 318 , no. 5854 . - P. 1258-1265 . - DOI : 10.1126 / science.1150577 . - PMID 17962520 .
- ↑ Rosenbaum DM, Cherezov V., Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK GPCR engineering yields high-resolution structural insights into β 2 -adrenergic receptor function ( English) // Science: journal. - 2007. - Vol. 318 , no. 5854 . - P. 1266-1273 . - DOI : 10.1126 / science.1150609 . - PMID 17962519 .
- ↑ 107 Nobel laureates sign letter blasting Greenpeace over GMOs
- ↑ Laureates Letter Supporting Precision Agriculture (GMOs)
- ↑ List of Nobel Laureates Signing the Letter
- ↑ ASPET JJ Abel Award . Date of treatment October 16, 2008. Archived December 13, 2012.
- ↑ Kobilka's work recognized in magazine award . Date of treatment October 16, 2008. Archived December 13, 2012.
- ↑ Franklyn A. Kobilka, 83 (unavailable link) . Date of treatment October 10, 2012. Archived December 9, 2012.
- ↑ Nobel winner a UMD grad who grew up in Little Falls
- ↑ Social Security Death Index
- ↑ The Kiewel Brewery
- ↑ Buchen, Lizzie. Cell signalling: It's all about the structure (Eng.) // Nature. - 2011 .-- 24 August ( vol. 476 , no. 7361 ). - P. 387-390 . - DOI : 10.1038 / 476387a .
Literature
- Kolesnikov S. S. Winners of the 2012 Nobel Prizeː In chemistry - R. Lefkowitz and B. Kobilka // Nature. - 2013. - No. 1. - S. 78-82.