Protoporphyrin IX (1,3,5,8-tetramethyl-2,4-divinyl-6,7-dipropionic acid porphin ) is synthesized during the metabolism of porphyrin by the enzyme protoporphyrinogen oxidase .
| Protoporphyrin IX | |
|---|---|
 | |
| Are common | |
| Chem. formula | C₃₄H₃₄N₄O₄ |
| Rac formula | C 34 H 34 N 4 O 4 |
| Physical properties | |
| Molar mass | 562.658 g / mol |
| Classification | |
| Reg. CAS number | 553-12-8 |
| Pubchem | |
| Reg. EINECS number | |
| SMILES | |
| Inchi | |
| CHEBI | |
| Chemspider | |
| Security | |
| NFPA 704 |  0 0 0 |
Content
Protoporphyrin IX Biosynthesis
Protoporphyrin IX is an important precursor to heme, cytochrome c and chlorophylls. As a result, many organisms are able to synthesize this tetrapyrrole from basic precursors, such as glycine and succinyl-CoA , and from glutamate . Despite the large phylogenetic variation of organisms capable of synthesizing protoporphyrin IX, this process remained virtually unchanged from bacteria to mammals, with several special exceptions in higher plants. [1] [2] [3]
Gem biosynthesis b
In heme biosynthesis, the enzyme ferrochelatase converts it into heme b (other names: Fe-protoporphyrin IX or protox IX).
Chlorophyll biosynthesis
In chlorophyll biosynthesis, the enzyme Mg-protoporphyrin chelatase transforms it into Mg-protoporphyrin IX .
See also
- Methylaminolevulinate
- Protoporphyrins
Sources
- ↑ AR Battersby, CJR Fookes, GWJ Matcham, E. McDonald. Biosynthesis of the pigments of life: formation of the macrocycle (eng.) // Nature: journal. - 1980. - Vol. 285 . P. 17-21 .
- ↑ FJ Leeper. The biosynthesis of porphyrins, chlorophylls, and vitamin B12 (Eng.) // Natural Product Reports : journal. - 1983. - Vol. 19 - P. 1137-1161 .
- ↑ G. Layer, J. Reichelt, D. Jahn. Structure and function of enzymes in heme biosynthesis (English) // Protein Science : journal. - 2010. - Vol. 19 - P. 1137-1161 .