Mupirocin (Bactroban, Bonderm) is a broad-spectrum antibacterial and bactericidal agent for external use.
| Mupirocin | |
|---|---|
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| Chemical compound | |
| IUPAC | 9 - [(E) -4 - [(2S, 3R, 4R, 5S) -3,4-dihydroxy-5 - [[(2S, 3S) -3- [(2S, 3S) -3-hydroxybutan-2 -yl] oxiran-2-yl] methyl] oxan-2-yl] -3-methylbut-2-enoyl] oxynonanoic acid |
| Gross formula | C 26 H 44 O 9 |
| Molar mass | 500.622 g / mol |
| Cas | |
| PubChem | |
| Drugbank | |
| Classification | |
| ATX | |
| Pharmacokinetics | |
| Plasma Protein Binding | 97% |
| The half-life. | 20-40 minutes |
| Other names | |
| Baktroban | |
Produced from Pseudomonas fluorescens .
Content
- 1 Pharmacological action
- 2 Indications
- 3 Contraindications
- 4 Side effects
- 5 Drug Interactions
- 6 with care
- 7 References
Pharmacological action
It acts bactericidal against infections caused by Staphylococcus aureus (including strains that are resistant to methicillin, Neisseria gonorrhoeae , Haemophilus influenzae , Neisseria meningitidis , Branhamella catarrhalis , Pasteurella multocida , Proteus mirabilis , Proteus vulbereroberoblobero vulgaris , pertussis .
Bactroban is not active against Corynebacterium spp. , Enterobacteriaceae spp. Micrococcus spp .
It inhibits isoleucine-transfer-RNA synthetase, which leads to impaired protein synthesis in bacteria.
Indications
- folliculitis ;
- impetigo ;
- furuncles ;
- ecthyma ;
- bacterial infections;
- infection prevention.
Contraindications
- hypersensitivity to the drug.
Side effects
Allergic reactions at the place of application of the drug.
Drug Interactions
The drug interaction of mupirocin with other drugs is poorly understood.
Caution
Mupirocin is used carefully for changes in kidney function. Avoid contact with eyes.
Links
- Mupirocin (Mupirocin): instructions, use and formula . Radar. Date of treatment July 16, 2012. Archived on October 7, 2012.
- Mupirocin . PubMed
- Mupirocin . Drugbank. Date of treatment July 15, 2012. Archived on October 7, 2012.