CD64

CD64 ( eng. Cluster of Differentiation 64 ) - membrane protein , glycoprotein, Fc receptor for monomeric immunoglobulins of IgG isotype with high affinity. ^[1] It is designated as Fc gamma receptor 1 (FcγRI). After IgG binding, the CD64 protein interacts with the gamma chain (γ chain), in which the ITAM motif is located, which triggers cellular activation. ^[2] There are 3 types of CD64: CD64A , CD64B and CD64C .

Content

Structure

CD64 consists of a signal peptide, 3 extracellular immunoglobulin domains of type C2 , which bind immunoglobulin, and a short cytoplasmic fragment. ^[3]

Tissue specificity

CD64 is constantly expressed only on macrophages and monocytes . It can be expressed on granulocytes after cell activation by cytokines, such as interferon-gamma IFNγ and G-CSF . ^[4] ^[5]

The presence of CD64 on the surface of neutrophils is a sign of infection and sepsis. ^[6]

Types

In humans, there are 3 similar proteins CD64: FcγRIA (CD64A), FcγRIB (CD64B) and FcγRIC (CD64C), all three of which are localized on chromosome 1 . ^[7]

Notes

Let Hulett M., Hogarth P. The second and third extracellular domains of the FcgammaRI (CD64) conferring the IgG2a (English) // Mol Immunol : journal. - 1998. - Vol. 35 , no. 14–15 . - P. 989-996 . - DOI : 10.1016 / S0161-5890 (98) 00069-8 . - PMID 9881694 .
↑ Nimmerjahn F., Ravetch J. Fcgamma receptors: // Immunity: journal. - Cell Press , 2006. - Vol. 24 , no. 1 . - P. 19-28 . - DOI : 10.1016 / j.immuni.2005.11.010 . - PMID 16413920 .
↑ Ernst L., Duchemin A., Miller K., Anderson C. Molecular characterization of the six variant Fcgamma receptor class I (CD64) transcripts (English) // Mol Immunol : journal. - 1998. - Vol. 35 , no. 14–15 . - P. 943-954 . - PMID 9881690 .
Uss Perussia B., Dayton E., Lazarus R., Fanning V., Trinchieri G. Immune interferon receptors for monomeric IgG1 on the human body : journal. - Rockefeller University Press , 1983. - Vol. 158 , no. 4 - P. 1092-1113 . - DOI : 10.1084 / jem.158.4.1092 . - PMID 6225822 .
↑ Repp R., Valerius T., Sendler A., Gramatzki M., Iro H., Kalden J., Platzer E. Neutrophils expressions for the IgG (Fc gamma RI, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor (English) // Blood : journal. - American Society of Hematology 1991. - Vol. 78 , no. 4 - P. 885-889 . - PMID 1714327 .
↑ Hoffmann JJ Neutrophil CD64 as a sepsis biomarker (Neopr.) // Biochem Med (Zagreb). - 2011. - Vol. 21 , No. 3 . - p . 282-290 . - PMID 22420242 .
↑ Ernst L., van de Winkel J., Chiu I., Anderson C. Fc receptor for IgGs (Fc gamma RI) encode four distinct transcription products (Eng.) // J Biol Chem : journal . - 1992. - Vol. 267 , no. 22 - P. 15692—15700 . - PMID 1379234 .

Literature

Thepen T., Huhn M., Melmer G., Tur MK, Barth S. Fcgamma receptor 1 (CD64), a target beyond cancer (Eng.) // Curr. Pharm. Des. : journal. - 2009. - Vol. 15 , no. 23 . - P. 2712-2718 . - PMID 19689341 .
Cid J., Aguinaco R., Sánchez R., García-Pardo G., Llorente A. Neutrophil CD64: a systematic review and meta-analysis (Eng.) // J. Infect. : journal. - 2010. - May ( vol. 60 , no. 5 ). - P. 313-319 . - DOI : 10.1016 / j.jinf.2010.02.013 . - PMID 20206205 .
Davis BH, Olsen SH, Ahmad E., Bigelow NC Neutrophil CD64 ( Arch. ) // Arch. Pathol. Lab. Med. : journal. - 2006. - May ( vol. 130 , no. 5 ). - P. 654-661 . - DOI : 10.1043 / 1543-2165 (2006) 130 [654: NCIAII] 2.0.CO; 2 . - PMID 16683883 .

Links

Immunology R. M. Khaitov, G. A. Ignatieva, I. G. Sidorovich, chapter 8.1.1. Fc receptors (rus.)

[1] Let Hulett M., Hogarth P. The second and third extracellular domains of the FcgammaRI (CD64) conferring the IgG2a (English) // Mol Immunol : journal. - 1998. - Vol. 35 , no. 14–15 . - P. 989-996 . - DOI : 10.1016 / S0161-5890 (98) 00069-8 . - PMID 9881694 .

[2] Nimmerjahn F., Ravetch J. Fcgamma receptors: // Immunity: journal. - Cell Press , 2006. - Vol. 24 , no. 1 . - P. 19-28 . - DOI : 10.1016 / j.immuni.2005.11.010 . - PMID 16413920 .

[Ernst_L,_Duchemin_A,_Miller_K,_Anderson_C_1998_943–54-3] Ernst L., Duchemin A., Miller K., Anderson C. Molecular characterization of the six variant Fcgamma receptor class I (CD64) transcripts (English) // Mol Immunol : journal. - 1998. - Vol. 35 , no. 14–15 . - P. 943-954 . - PMID 9881690 .

[4] Uss Perussia B., Dayton E., Lazarus R., Fanning V., Trinchieri G. Immune interferon receptors for monomeric IgG1 on the human body : journal. - Rockefeller University Press , 1983. - Vol. 158 , no. 4 - P. 1092-1113 . - DOI : 10.1084 / jem.158.4.1092 . - PMID 6225822 .

[5] Repp R., Valerius T., Sendler A., Gramatzki M., Iro H., Kalden J., Platzer E. Neutrophils expressions for the IgG (Fc gamma RI, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor (English) // Blood : journal. - American Society of Hematology 1991. - Vol. 78 , no. 4 - P. 885-889 . - PMID 1714327 .

[6] Hoffmann JJ Neutrophil CD64 as a sepsis biomarker (Neopr.) // Biochem Med (Zagreb). - 2011. - Vol. 21 , No. 3 . - p . 282-290 . - PMID 22420242 .

[7] Ernst L., van de Winkel J., Chiu I., Anderson C. Fc receptor for IgGs (Fc gamma RI) encode four distinct transcription products (Eng.) // J Biol Chem : journal . - 1992. - Vol. 267 , no. 22 - P. 15692—15700 . - PMID 1379234 .