N-cadherin (neuronal cadherin; cadherin-2, type 1 ; CDH2, CD325 ) is a membrane protein , a glycoprotein from the cadherin superfamily, the product of the CDH2 gene. The gene was first cloned in 1990 . [one]
| N-cadherin, cadherin-2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB is drawn based on 1ncg. | |||||||||||||
| Identifiers | |||||||||||||
| Symbol | ; CD325; CDHN; CDw325; NCAD | ||||||||||||
| External id | ChEMBL : GeneCards : | ||||||||||||
| |||||||||||||
| RNA expression profile | |||||||||||||
 | |||||||||||||
 | |||||||||||||
| Ortologists | |||||||||||||
| View | Person | Mouse | |||||||||||
| Entrez | |||||||||||||
| Ensembl | |||||||||||||
| UniProt | |||||||||||||
| RefSeq (mRNA) | |||||||||||||
| RefSeq (protein) | |||||||||||||
| Locus (UCSC) | |||||||||||||
| PubMed Search | |||||||||||||
Functions
N-cadherin together with E- and P-cadherins refers to the 1st type of cadherin, calcium- dependent proteins of cell adhesion. They are involved in homophilic interactions, forming cell-cell contacts. N-cadherin is involved in the mechanism of neuronal recognition. In hippocampal neurons, it can regulate the density of dendritic spines . [2]
Structure
N-cadherin consists of 747 amino acids (after maturation), the molecular weight of the protein part is 99.8 kDa . The main N-terminal site (565 amino acids) is extracellular, then there is a single transmembrane fragment and an intracellular fragment (161 amino acids). The extracellular fragment includes 5 repeats of the cadherin domain and from 4 to 7 N-glycosylation sites . The cytosol fragment contains a phosphorylation site (on the tyrosine residue).
Interacts with CDCP1. Detected in conjunction with FGFR4, NCAM1 , PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8, forming a complex that can contain TAOK2 and internalize through a mechanism mediated by TAOK2 / p38 MAPK.
See also
- Cadherins
- Differentiation cluster
Notes
- ↑ Reid RA, Hemperly JJ Human N-cadherin: the nucleotide and deduced amino acid sequence (eng.) // Nucleic Acids Res. : journal. - 1990. - October ( vol. 18 , no. 19 ). - P. 5896 . - PMID 2216790 .
- ↑ Uniprot database entry for CD325 (accession number P19022)
Bibliography
- Becker SF, Langhe R., Huang C., Wedlich D., Kashef J. Cadherins in tissue movements (Eng.) // Archives of Biochemistry and Biophysics : journal. - Elsevier , 2012. - March. - DOI : 10.1016 / j.abb.2012.02.013 . - PMID 22387375 .
- Brigidi GS, Bamji SX Cadherin-catenin adhesion groups at the synapse (Neopr.) // Curr. Opin. Neurobiol .. - 2011. - April ( vol. 21 , No. 2 ). - p . 208-214 . - DOI : 10.1016 / j.conb.2010 . - PMID 21255999 .