Integrin alpha-10 (α10) is a membrane protein , a glycoprotein from the superfamily of integrins , a product of the ITGA10 gene , alpha-subunit of integrin α10β1, a receptor for collagen .
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| , PRO827, integrin subunit alpha 10 | |||||||||||||
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Content
Functions
Integrin alpha-10 / beta-1 (α10β1) is a receptor for collagen . [one]
Structure
Integrin alpha-10 is a large protein, consists of 1145 amino acids , the molecular weight of the protein part is 127.6 kDa . The N-terminal portion (1100 amino acids) is extracellular, then the only transmembrane fragment and a small intracellular fragment (22 amino acids) are located. The extracellular fragment includes 7 FG-GAP repeats, VWFA domain, up to 11 N-glycosylation sites . The cytosolic region includes the GFFKR motif.
Integrin alpha-10 refers to integrins with I-domain (VWFA domain), which do not undergo limited proteolysis during maturation. Alternative splicing leads to the formation of 2 isoforms.
Tissue specificity
Integrin α10β1 is widely present in various tissues, the highest level of expression in muscles and heart. It is also present in articular cartilage .
See also
- Integrins
Notes
Bibliography
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- Camper L., Hellman U., Lundgren-Akerlund E. Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes (English) // J. Biol. Chem. : journal. - 1998. - Vol. 273 , no. 32 . - P. 20383-20389 . - DOI : 10.1074 / jbc.273.32.20383 . - PMID 9685391 .
- Bengtsson T., Camper L., Schneller M., Lundgren-Akerlund E. Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants (English) // Matrix Biol. : journal. - 2001. - Vol. 20 , no. 8 . - P. 565-576 . - DOI : 10.1016 / S0945-053X (01) 00164-0 . - PMID 11731273 .
- Brakebusch C., Hirsch E., Potocnik A., Fässler R. Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules (Eng.) // Journal of Cell Science : journal. - The Company of Biologists 1997. - Vol. 110 , no. 23 . - P. 2895-2904 . - PMID 9359872 .
- Clark HF, Gurney AL, Abaya E., et al. The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment (Eng.) // Genome Res. : journal. - 2003. - Vol. 13 , no. 10 . - P. 2265-2270 . - DOI : 10.1101 / gr.1293003 . - PMID 12975309 .
- Lehnert K., Ni J., Leung E., et al. The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization (English) // Cytogenetic and Genome Research : journal. - Karger Publishers , 1999. - Vol. 87 , no. 3-4 . - P. 238-244 . - DOI : 10.1159 / 000015434 . - PMID 10702680 .
- Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences (Eng.) // Proceedings of the National Academy of Sciences of the United States of America : journal. - 2002. - Vol. 99 , no. 26 . - P. 16899-16903 . - DOI : 10.1073 / pnas.242603899 . - PMID 12477932 .
- Svoboda KK Chondrocyte-matrix attachment complexes mediate survival and differentiation // Microsc. Res. Tech. : journal. - 1998. - Vol. 43 , no. 2 . - P. 111-122 . - DOI : 10.1002 / (SICI) 1097-0029 (19981015) 43: 2 <111 :: AID-JEMT4> 3.0.CO; 2-O . - PMID 9822998 .
- Bengtsson T., Aszodi A., Nicolae C., et al. Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes (Eng.) // Journal of Cell Science : journal. - The Company of Biologists 2005. - Vol. 118 , no. Pt 5 . - P. 929-936 . - DOI : 10.1242 / jcs.01678 . - PMID 15713743 .
- Wenke AK, Rothhammer T., Moser M., Bosserhoff AK Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1 (Eng.) // Biochem. Biophys. Res. Commun. : journal. - 2006. - Vol. 345 , no. 1 . - P. 495-501 . - DOI : 10.1016 / j.bbrc.2006.04.123 . - PMID 16684505 .