Integrin alpha-5 (α5, CD49e ) is a membrane protein , a glycoprotein from the superfamily of integrins , a product of the ITGA5 gene, alpha-subunit of integrin α5β1 ( VLA-5 ), one of the main receptors of fibronectin . It plays a role in intercellular interactions.
| Integrin alpha-5 | |||||||||||||
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| Symbol | ; CD49e; FNRA VLA5A | ||||||||||||
| External IDs | ChEMBL : GeneCards : | ||||||||||||
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Content
- 1 Functions
- 2 Structure
- 3 notes
- 4 See also
- 5 Bibliography
- 6 References
Functions
Integrin alpha-5 / beta-1 (α5β1, English very late antigen-5 , VLA-5 ) is a receptor for fibronectin and fibrinogen . Recognizes the specific amino acid sequence of glycine-proline-arginine (RGD) in a wide range of ligands. During HIV infection, interaction with the viral Tat peptide enhances angiogenesis in Kaposi’s sarcoma [1] .
It interacts with intracellular proteins HPS5 , NISCH , as well as with RAB21 and COMP. Binds to Tat peptide of HIV-1 virus.
Structure
Integrin alpha-5 is a large protein, consists of 1008 amino acids , the molecular weight of the protein part is 114.5 kDa . The N-terminal portion (954 amino acids) is extracellular, then there is a single transmembrane fragment and a short intracellular fragment (28 amino acids). The extracellular fragment includes 7 FG-GAP repeats, SG1 motif involved in the interaction with chondroitin sulfates, and from 5 to 15 N-glycosylation sites . The cytosolic region includes the GFFKR motif and the HPS5 binding region.
In the process of limited proteolysis, the intramolecular bond is hydrolyzed and a heavy and light chain linked by a disulfide bond are formed .
Notes
See also
- Integrins
- Differentiation cluster
Bibliography
- Morgan MR, Byron A., Humphries MJ, Bass MD Giving off mixed signals - distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behavior (Eng.) // IUBMB Life: journal. - 2009 .-- July ( vol. 61 , no. 7 ). - P. 731-738 . - DOI : 10.1002 / iub.200 . - PMID 19514020 .
- Rüegg C., Alghisi GC Vascular integrins: therapeutic and imaging targets of tumor angiogenesis (Eng.) // Recent Results Cancer Res. : journal. - 2010 .-- Vol. 180 . - P. 83-101 . - DOI : 10.1007 / 978-3-540-78281-0_6 . - PMID 20033379 .
- Ruoslahti E. Integrin signaling and matrix assembly. (English) // Tumour Biol. : journal. - 1996. - Vol. 17 , no. 2 . - P. 117-124 . - DOI : 10.1159 / 000217975 . - PMID 8658014 .
- Coulombel L., Auffray I., Gaugler MH, Rosemblatt M. Expression and function of integrins on hematopoietic progenitor cells. (English) // Acta Haematol. : journal. - 1997. - Vol. 97 , no. 1-2 . - P. 13-21 . - DOI : 10.1159 / 000203655 . - PMID 8980606 .
- Porter JC, Hogg N. Integrins take partners: cross-talk between integrins and other membrane receptors (Eng.) // Trends Cell Biol. : journal. - 1999. - Vol. 8 , no. 10 . - P. 390-396 . - DOI : 10.1016 / S0962-8924 (98) 01344-0 . - PMID 9789327 .
- Evans JP Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization (English) // Bioessays : journal. - 2001. - Vol. 23 , no. 7 . - P. 628-639 . - DOI : 10.1002 / bies.1088 . - PMID 11462216 .