TNFSF14

TNFSF14
Available structures
PDB	Search for orthologs: PDBe , RCSB
PDB ID List
	, , ,
Identifiers
Symbol	; CD258; HVEML; LIGHT; LTg; TR2
External id	GeneCards :
Gene ontology
Function	•; •; •; •; •;
Cell component	•; •; •; •;
Biological process	•; •; •; •; •; •; •; •; •; •; •;
	Sources: Amigo / QuickGO
RNA expression profile
Ortologists

TNFSF14 (a member of the superfamily (ligands) of tumor necrosis factors 14, English tumor necrosis factor (ligand) superfamily member 14 ) is an extracellular protein , a proinflammatory cytokine from the superfamily of tumor necrosis factors ( TNF ).

Functions

TNFSF14 activates the nuclear transcription factor NF-kB , stimulates the proliferation of T-lymphocytes , inhibits the growth of HT-29 adenocarcinoma. In addition, it is a receptor for the Herpes simplex virus.

Structure

It exists in two forms: full membrane-bound (240 amino acids ) with a molecular weight of 26.35 kDa and free, or soluble, which is formed after the removal of the first approx. 82 amino acids (158 amino acids). The membrane form contains cytosolic, transmembrane and extracellular regions. Soluble form includes only extracellular fragment. TNFSF14 forms a trimer. ^[one]

Tissue specificity

Basically located in the spleen, to a lesser extent - in the brain . Poorly represented in peripheral lymphoid tissue, placenta, liver, lung, vermiform process and in the kidneys.

Interactions

TNFSF14 interacts with receptors TNFRSF14 , ^[2] ^[3] TNFRSF6B , ^[2] ^[3] ^[4] and signaling proteins BIRC2 , ^[5] TRAF2 ^[5] and TRAF3 . ^[five]

Role in Asthma

TNFSF14 plays a role in the induction of fibrosis and hyperplasia of smooth muscle cells in bronchial asthma . ^[6]

Notes

↑ Uniprot database entry for CD258 (accession number O43557)
↑ ¹ ² Zhang, J; Salcedo T W., Wan X., Ullrich S., Hu B., Gregorio T., Feng P., Qi S., Chen H., Cho Y H., Li Y., Moore P. A., Wu J. Modulation of T-cell responses to alloantigens by TR6 / DcR3 (English) // J. Clin. Invest. : journal. - United States, 2001 . - June ( vol. 107 , no. 11 ). P. 1459-1468 . - ISSN 0021-9738 . - DOI : 10.1172 / JCI12159 . - PMID 11390428 .
↑ ¹ ² Yu, KY; Kwon B., Ni J., Zhai Y., Ebner R., Kwon B S. LIGHT-mediated apoptosis (Eng.) // J. Biol. Chem. : journal. - UNITED STATES, 1999 . - May ( vol. 274 , no. 20 ). - P. 13733-13736 . - ISSN 0021-9258 . - DOI : 10.1074 / jbc.274.20.13733 . - PMID 10318773 .
↑ Hsu, Tsui-Ling; Chang Yung-Chi, Chen Siu-Ju, Liu Yong-Jun, Chiu Allen W., Chio Chung-Ching, Chen Lieping, Hsieh Shie-Liang. Modulation of dendritic cell differentiation and maturation by decoy receptor 3 (Eng.) // J. Immunol. : journal. - United States, 2002 . - May ( vol. 168 , no. 10 ). P. 4846-4853 . - ISSN 0022-1767 . - PMID 11994433 .
↑ ¹ ² ³ Kuai, Jun; Nickbarg Elliott, Wooters Joe, Qiu Yongchang, Wang Jack, Lin Lih-Ling. The endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis (Eng.) // J. Biol. Chem. : journal. - United States, 2003 . - April ( vol. 278 , no. 16 ). - P. 14363-14369 . - ISSN 0021-9258 . - DOI : 10.1074 / jbc.M208672200 . - PMID 12571250 .
↑ Doherty TA, Soroosh P., Khorram N., et al. The tumor necrosis factor in the family member is a target for asthmatic airway remodeling (Eng.) // Nat. Med. : journal. - 2011. - May ( vol. 17 , no. 5 ). - P. 596-603 . - DOI : 10.1038 / nm.2356 . - PMID 21499267 .

Literature

Yang D., Zhai Y., Zhang M. LIGHT, a new member of the TNF superfamily (Eng.) // J. Biol. Regul. Homeost. Agents. - 2003. - Vol. 16 , no. 3 - P. 206-210 . - PMID 12456019 .
Bénichou S., Benmerah A. [The HIV nef and the Kaposi-sarcoma-associated virus K3 / K5 proteins: "parasites" of the endocytosis pathway] (eng.) // Med Sci (Paris): journal. - 2003. - Vol. 19 , no. 1 . - P. 100-106 . - DOI : 10.1051 / medsci / 2003191100 . - PMID 12836198 .

[Uniprot-1] Uniprot database entry for CD258 (accession number O43557)

[pmid11390428-2] ¹ ² Zhang, J; Salcedo T W., Wan X., Ullrich S., Hu B., Gregorio T., Feng P., Qi S., Chen H., Cho Y H., Li Y., Moore P. A., Wu J. Modulation of T-cell responses to alloantigens by TR6 / DcR3 (English) // J. Clin. Invest. : journal. - United States, 2001 . - June ( vol. 107 , no. 11 ). P. 1459-1468 . - ISSN 0021-9738 . - DOI : 10.1172 / JCI12159 . - PMID 11390428 .

[pmid10318773-3] ¹ ² Yu, KY; Kwon B., Ni J., Zhai Y., Ebner R., Kwon B S. LIGHT-mediated apoptosis (Eng.) // J. Biol. Chem. : journal. - UNITED STATES, 1999 . - May ( vol. 274 , no. 20 ). - P. 13733-13736 . - ISSN 0021-9258 . - DOI : 10.1074 / jbc.274.20.13733 . - PMID 10318773 .

[pmid11994433-4] Hsu, Tsui-Ling; Chang Yung-Chi, Chen Siu-Ju, Liu Yong-Jun, Chiu Allen W., Chio Chung-Ching, Chen Lieping, Hsieh Shie-Liang. Modulation of dendritic cell differentiation and maturation by decoy receptor 3 (Eng.) // J. Immunol. : journal. - United States, 2002 . - May ( vol. 168 , no. 10 ). P. 4846-4853 . - ISSN 0022-1767 . - PMID 11994433 .

[pmid12571250-5] ¹ ² ³ Kuai, Jun; Nickbarg Elliott, Wooters Joe, Qiu Yongchang, Wang Jack, Lin Lih-Ling. The endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis (Eng.) // J. Biol. Chem. : journal. - United States, 2003 . - April ( vol. 278 , no. 16 ). - P. 14363-14369 . - ISSN 0021-9258 . - DOI : 10.1074 / jbc.M208672200 . - PMID 12571250 .

[6] Doherty TA, Soroosh P., Khorram N., et al. The tumor necrosis factor in the family member is a target for asthmatic airway remodeling (Eng.) // Nat. Med. : journal. - 2011. - May ( vol. 17 , no. 5 ). - P. 596-603 . - DOI : 10.1038 / nm.2356 . - PMID 21499267 .