CD69 (an early antigen of activation of T-lymphocytes CD69) - a membrane protein , glycoprotein , refers to type C lectins , is an early marker of lymphocyte proliferation. It plays a role in inflammation. [one]
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 PDB is drawn on 1e87. | |||||||||||||
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| Symbol | ; AIM BL-AC / P26; CLEC2C; EA1; GP32 / 28; MLR-3 | ||||||||||||
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Content
Structure
Protein CD69 refers to integral transmembrane proteins , contains 199 amino acids . The molecular weight is 22.6 kDa. The extracellular fragment contains a lectin domain. Forms a homodimer bound by a disulfide bond . In addition, the protein contains three intramolecular disulfide bonds.
Functions
Participates in the proliferation of lymphocytes, functions as a signal transfer receptor in lymphocytes, natural killers and platelets . It is the earliest marker of lymphocyte proliferation, which is widely used in immunological studies and diagnostics.
Tissue specificity
The protein is expressed on the surface of activated T- and B-lymphocytes , natural killers, neutrophils , eosinophils , epidermal Langerhans cells and platelets.
Notes
- ↑ Hasegawa A., Nakayama T. [Role of CD69 in the pathogenesis of inflammation] (Japanese) // Nihon Rinsho Meneki Gakkai Kaishi. - 2010. - 第 33 巻 , 第 4 数 . - 第 189-195 頁 . - PMID 20818147 .
Bibliography
- Cambiaggi C., Scupoli MT, Cestari T., et al. Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12. (Eng.) // Immunogenetics: journal. - 1992. - Vol. 36 , no. 2 . - P. 117-120 . - DOI : 10.1007 / BF00215288 . - PMID 1612643 .
- Lichtfuss GF, Hoy J., Rajasuriar R., Kramski M., Crowe SM, Lewin SR Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection (Eng.) // Biomark Med : journal. - 2011 .-- April ( vol. 5 , no. 2 ). - P. 171-186 . - DOI : 10.2217 / bmm.11.15 . - PMID 21473720 .