Nicocodein

Nicocodein ( 6-Nicotinoylcodeine , Lyopect, Tusscodin ) is an opiate derivative closely associated with dihydrocodeine and the codeine analogue of nicomorphine , developed to combat cough and is an analgesic . It is not common in most countries, but its activities are similar to other opiates. Nicocodein and nicomorphine were introduced by Lannacher Heilmittel in the late 1950s. Nicocodein is metabolized in the liver by demethylation, producing nicomorphine, also known as 6-nicotinolmorphine, and is subsequently metabolized to morphine . Side effects are similar to other opiates and include itching , nausea, and respiratory depression .

Nicocodein
Nicocodeine
Chemical compound
IUPAC	(5α, 6α) -3-methoxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-yl nicotinate
Gross formula	C 24 H 24 N 2 O 4
Molar mass	404.458 g / mol
Cas
PubChem
Classification
Pharmacokinetics
Metabolism	in the liver , with CYP2D6 enzyme (Cytochrome P450 2D6) [1]
Other names
Lyopect, Tusscodin

Nicocodein is regulated in most cases as codeine. Weak opioids like it, such as ethyl morphine , benzyl morphine , dihydrocodeine and other related derivatives such as acetyldihydrocodeine and other opioids of this class are regulated by the laws of the country and the Single Convention on Narcotic Drugs. One striking example is that nicocodein is on the “List I / Narcotic Substances” included by the United States along with heroin, and nicocodein has never been used for medical use in the United States.

Nicodecodein is similar to nicocodein as much as codeine is similar to dihydrocodeine. Nicodicodein metabolites include dihydromorphine .

Nicocodein-based cough medicines are available in the form of syrups, sustained-action syrups and sublingual drops. Analgesics also come in the form of sublingual drops, or tablets for oral use. The strength of the example nicocodein is equal to hydrocodone .