Correlizer is a scientific nonprofit project of voluntary computing on the BOINC platform , using free computing resources on volunteer computers to study the spatial organization of the genome.
| Correlizer | |
|---|---|
| Type of | Distributed computing |
| Interface languages | English |
| Hardware platform | Cross-platform software |
| Site | svahesrv2.bioquant.uni-heidelberg.de/... |
About the project
The research team (which also includes our people from MIT) showed that the DNA chain in the nucleus of the cell is folded into a tight ball, while preventing any nodes and ligaments that could prevent the cell from “reading” its own genome. In mathematical terms, the pieces of the genome add up to something similar to the Gilbert curve.
The spatial organization of chromosomes is crucial for the regulation of the genome. This opens up new aspects of gene regulation that were not previously available for research. The relationship of the form of the genome with the function of the gene can help explain the relationship between genes and diseases, which remain largely unexplained by traditional nucleotide sequence-focused genomics. It is also unknown how the shape of the genome is changing. Apparently, this happens constantly during the transition from stem cells to an adult cell, and then during the functioning of the cell.
Links
- http://svahesrv2.bioquant.uni-heidelberg.de - official site of the Correlizer project
- About the genome
- Who organizes distributed computing and who participates in them?
See also
- Voluntary Computing
- Boinc
- Genomics