Benzidamine is a drug, a non-steroidal anti-inflammatory drug that has analgesic, antipyretic and anti-inflammatory effects. It is used to reduce postoperative and post-traumatic pain and edema , and promotes wound healing . The drug is also used externally in the treatment of rheumatic diseases and inflammation of the mouth and throat . [one]
| Benzidamine | |
|---|---|
 | |
| Chemical compound | |
| IUPAC | 3- (1-benzyl-1 H -indazol-3-yloxy) - N, N -dimethylpropan-1-amine |
| Gross formula | C 19 H 23 N 3 O |
| Molar mass | 309.405 g / mol |
| Cas | |
| PubChem | |
| Drugbank | |
| Classification | |
| ATX | |
| Pharmacokinetics | |
| Plasma Protein Binding | <20% |
| The half-life. | 13 hours |
| Excretion | the kidneys |
| Dosage Forms | |
| Spray, lozenges | |
| Route of administration | |
| orally, topically | |
| Other names | |
| Tantum Verde, Tenflex, Oralsept, Tantum Rose, T-Sept | |
In infectious and inflammatory diseases, it is used only as part of combination therapy.
Content
- 1 Indications
- 2 Pharmacology
- 3 Recreational use
- 4 notes
Indications for use
Benzidamine, available primarily in the form of a liquid mouthwash, oromucosal spray or local cream, is most often used as a local anesthetic and anti-inflammatory agent to relieve painful inflammatory conditions.
When used as a mouthwash or spray, benzidamine can be used to treat traumatic conditions following tonsillectomy or the use of an endotracheal tube , inflammatory conditions such as pharyngitis, aphthous ulcers and oral ulcers as a result of radiation therapy , dental surgery and procedures , or more general conditions such as sore throat, tongue pain, sore gums, mouth ulcers or discomfort caused by dentures.
When used as a topical cream, benzidamine can be used to relieve symptoms associated with painful inflammatory conditions of the musculoskeletal system, including acute inflammatory disorders such as myalgia and bursitis, or traumatic conditions such as sprains, strains, bruises, pain in muscles, joint dislocations, or even the consequences of fractures. [2]
Pharmacology
Unlike other non-steroidal anti-inflammatory drugs, benzidamine does not inhibit cyclooxygenase or lipoxygenase and, presumably, does not cause corresponding side effects. [3]
According to the developer of the drug, it reduces capillary permeability, stabilizes lysosomal membranes, inhibits the production of ATP , other macroergic compounds in oxidative phosphorylation, inhibits the synthesis or inactivates prostaglandins , histamine , bradykinins , cytokines , complement factors and other non-specific endogenous “damaging factors”. It blocks the interaction of bradykinin with tissue receptors, restores impaired microcirculation and reduces pain sensitivity in the focus of inflammation. It affects the thalamic centers of pain sensitivity (local blockade of the synthesis of PgE1, PgE2 and PgF2 alpha). The analgesic effect is due to an indirect decrease in the concentration of biogenic amines with algogenic properties, and an increase in the threshold of pain sensitivity of the receptor apparatus.
When applied topically, it is well absorbed through the mucous membranes and quickly penetrates into inflamed tissues. It is excreted by the kidneys in the form of metabolites and through the intestines.
Recreational Use
Benzidamine is used for recreation . An overdose of the drug causes the effect of anticholinergic hallucinogens and stimulation of the central nervous system. [3] Similar use, in particular, among adolescents is common in Poland , [3] Brazil [4] [5] and Romania .
Notes
- ↑ Turnbull RS. Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions. // J Can Dent Assoc .. - 1995. - PMID 7600413 .
- ↑ Benzidamine (Tantum Verde solution) . Zbibiz ( 02/20/2019 ). Date of treatment March 12, 2019.
- ↑ 1 2 3 Anand JS, Glebocka ML, Korolkiewicz RP. Recreational abuse with benzydamine hydrochloride (tantum rosa). // Clin Toxicol (Phila). - 2007. - PMID 17364645 .
- ↑ Opaleye ES, Noto AR, Sanchez ZM, Moura YG, Galduróz JC, Carlini EA. Recreational use of benzydamine as a hallucinogen among street youth in Brazil. // Rev Bras Psiquiatr. - 2009. - PMID 19784487 .
- ↑ Mota DM, Costa AA, Teixeira Cdos S, Bastos AA, Dias MF. Use abusive of benzydamine in Brazil: an overview in pharmacovigilance. // Cien Saude Colet. - 2010. - PMID 20464184 .