Lamivudine / Zidovudine (trade name Eng. Combivir ) - a treatment for HIV infection, contains two antiretroviral drugs, such as lamivudine ( Epivir brand ) and zidovudine (AZT, Retrovir brand). The combination of two drugs causes a stronger and more stable effect than when using these drugs alone, helps to reduce polypharmacy , and also helps to clearly adhere to the regimen of antiretroviral drugs.
| Lamivudine / Zidovudine | |
|---|---|
| Structure | |
| Gross formula | C 18 H 24 N 8 O 7 S |
| Cas | |
| PubChem | |
| Drugbank | |
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| Classification | |
| ATX | |
| Dosage Forms | |
| Pills | |
| Route of administration | |
| Orally | |
| Other names | |
| Combivir | |
Lamivudine and zidovudine are reverse transcriptase inhibitors that block the action of this enzyme, which is necessary for virus replication . Reduce the viral load on the body and increase the level of CD4 lymphocytes .
Combivir is approved in the United States by the Food and Drug Administration on September 26, 1997 , making it the thirteenth approved antiretroviral agent.
Side Effects
Taking Combivir, as a rule, is accompanied by a feeling of pain and fatigue.
In general, the side effects of the drug correspond to its components: zidovudine and lamivudine .