Entoban is an anti - diarrheal phytopreparation made up of extracts of medicinal plants that have antidiarrheal, antibacterial, antiprotozoal, anti-inflammatory and enveloping properties in the form of syrup or capsules .
Content
Composition
10 ml of syrup contains a thick extract of fluffy Holarchena bark - 25 mg, a thick extract of Myrtle ordinary fruit - 70.5 mg, a thick extract of spinach barberry - 10.6 mg, a thick extract of Quince bengal fruit - 30.5 mg, a thick extract of Oak fruit dyeing agent - 15.2 mg, a thick extract of excellent Buteya resin - 8.2 mg, as well as excipients: sugar, glycerin, sodium chloride, citric acid, methylparaben, propylparaben , tutti frutti essence, peppermint oil, propylene glycol, purified water.
1 capsule contains: 131 mg of fluffy Holarchena bark, 131 mg of Myrtle ordinary fruit, 32 mg of Spiny barberry fruit, 32 mg of Bengal quince fruit, 32 mg of dyeing oak, 2 mg of magnificent Buteya resin, and excipients: 100 mg of talc . The capsule shell consists of gelatin , purified water, sodium lauryl sulfate, methyl paraben, propyl paraben, dyes (brilliant blue, yellow (quinoline) and sunset color) and titanium dioxide.
Description of the drug
A brown syrupy liquid with a characteristic odor and sweet taste.
The action of the drug Entoban is determined by the combination of actions of its components. In this regard, kinetic observations are impossible. Components cannot be traced using markers or bioassays, which makes it impossible to detect drug metabolites. Being a combined herbal medicine, Entoban has antidiarrheal, antibacterial and antiprotozoal effects.
- Holarhen fluffy . Contains alkaloids of the steroid type of the conessin series. It has antimicrobial and anti-amoebic activity.
- Myrtle ordinary . Contains myrtle oil, tannins, bitterness. It has a bactericidal (especially against staphylococci and streptococci), antiviral, fungicidal, antiprotozoal and anti-inflammatory effects. Stimulates regeneration processes. Bitterness - increase the secretion of digestive glands, improve digestion.
- Barberry spinous . It contains alkaloids (berberine, berbamine), sugars, tannins, pectin, vitamins (C, K), organic acids (malic, tartaric, citric, etc.), microelements (P, K, Ca, Mg, Fe). It has anti-inflammatory, antidiarrheal, astringent and antiseptic effects. Berberine alkaloid has a pronounced antibacterial activity.
- Quince Bengal . Contains glycoside marmelosin, azulenes, tannins and pectin, coumarins, essential oils, gums, mucus, vitamin B2. It has astringent, antidiarrheal, anti-inflammatory and antiseptic properties. It has a hypoglycemic effect, promotes digestion of food.
- Oak is dyeing . Contains gallotannin, tannins. It has astringent, anti-inflammatory and antimicrobial effects.
- Buteya is magnificent . Contains glycosides, glycine, butine. It has astringent and anthelmintic properties.
| Flower of myrtle ordinary. | Barberry. | Quince. | Oak leaves. | Butea is single-seeded. |
The connesin contained in the preparation has an antiseptic and antiprotozoal effect - a decrease in the duration and strength of the effect of pathogenic agents on the gastrointestinal tract. Due to the presence of gums, mucus, tannins - the drug protects enterocytes from the effects of enterotoxins, reduces toxicosis. Due to the astringent effect, a thickening of the intestinal basement membrane occurs, which helps to reduce toxicosis and reduce hypersecretion of water into the intestinal lumen. As a result, a decrease in fluid and electrolyte losses, a decrease in the rate of dehydration, and an improvement in microcirculation. The positive effects of Entoban contribute to a more favorable course of OCI.
The use of the drug
Indications for the appointment and administration of Entoban are such nosologies as diarrhea , dysentery (including acute amoebic and bacterial), intestinal amebiasis , acute gastroenteritis and foodborne toxicosis . Entoban can be used as part of complex therapy. The drug is taken regardless of the meal. Currently, no cases of drug overdose have been described.
| age category | Syrup | Capsules | |
|---|---|---|---|
| Children | from 6 months to 3 years | ½ teaspoon every 4 hours | - |
| from 3 to 8 years | 1 teaspoon every 4 hours | ||
| from 8 to 18 years | 2 teaspoon every 4 hours | ||
| Adults | 3-4 teaspoons every 4 hours | The initial dose is 2 capsules, then 1 capsule every 4 hours | |
An allergic reaction to various components of the drug is considered to be a side effect on the intake of Entoban. Thus, Entoban is contraindicated in case of increased individual sensitivity to the components of the drug, pregnancy and during the lactation period. Patients with diabetes mellitus, exudative diathesis, and those on a low-calorie diet should be aware that the syrup contains sucrose . However, unwanted drug interactions of Entoban with other drugs and drugs were not observed.
Clinical
Determining Efficiency and Safety
Clinical studies to determine the effectiveness and safety of Entoban were conducted in 2003 in the intestinal ward of Tashkent Children's Infectious Diseases Hospital No. 4. The study involved 20 children, aged 1 month to 4 years, who were diagnosed with the following: acute diarrhea, dysentery, salmonellosis , escherichiosis. The duration of therapy was indicated in the range from 2 to 5 days. According to the dosing regimen established during testing, Entoban in syrup was taken 1 teaspoon every 4 hours, while the initial dose of Entoban in capsules was 2 capsules, and then (with repeated use) - 1 capsule every 4 hours.
| period of time | Chair character | Stool frequency | Scatology |
|---|---|---|---|
| 2 days | Partial normalization of stool [1] in 12 participants. | Decreased stool frequency. | Reduction of mucus and leukocytes in the feces, the disappearance of red blood cells in the feces in 12 patients. |
| 4 days | Complete stool normalization. | The disappearance of signs of inflammation of the intestinal mucosa. |
“A study of the effectiveness of Entoban in the treatment of sick children and adolescents with secretory diarrhea”
The results of a study conducted at the Department of Infectious Diseases and Epidemiology of the Lugansk Medical University and the Lugansk Regional Children's Infectious Diseases Hospital. The study involved 80 children and adolescents aged 4 to 18 years. The diagnoses are Escherichiosis, salmonellosis, rotavirus enteritis, foodborne toxicoinfections caused by opportunistic microorganisms.
In the main group, there was a more rapid disappearance of symptoms of ACI. In particular: reduction in the duration of diarrhea, toxicosis. Shortening postinfectious asthenia. The amount of residual phenomena after acute intestinal infections in the main group was 1.6 times less than in the control group.
| The nature and frequency of the stool | The main group (n = 43), abs.h /% | Control group (n = 37), abs.h /% | Difference | R |
|---|---|---|---|---|
| Reducing the volume and frequency of watery bowel movements on the second day of treatment | 22 (51.1%) | 14 (38%) | 1.3 times | > 0.1 |
| Improving the consistency of the stool (thickened mushy) on the third day of treatment | 34 (79%) | 22 (59.2%) | 1.3 times | > 0.05 |
| Stool normalization on the fifth day of treatment | 38 (88.3%) | 29 (78.3%) | 1.3 times | > 0.05 |
The results of a co-cytogram during a repeated study showed a positive effect in the restoration of digestion function. A decrease in the amount of fatty acids, the disappearance of muscle fibers, a decrease in the number of starch grains, and a decrease in the amount of digestible fiber were noted. findings
- The use of Entoban in the treatment of sick children and adolescents with acute intestinal infections with secretory diarrhea has a positive effect on the clinical course of the disease.
- A decrease in the duration of diarrheal syndrome and infectious toxicosis by an average of 1.8 days
- Shortening the period of post-infectious asthenia by 2.8 days in comparison with the control group.
- The frequency of bowel movements decreases and the nature of the stool improves.
- Fluid loss is reduced from the second day of treatment in half of patients, preventing dehydration.
- Helps to improve digestion function, restore within 3-5 days indicators of the coprogram
- Reduces the incidence of residual events in patients with acute acute respiratory infections
- Helps to update the morphological and functional parameters of microcirculation, which positively affects the restoration of microhemodynamics in acute
Notes
- ↑ T. e. A decrease in mucus, blood, greens, improving the consistency of the stool
Links
- Official site
- vidal.ru
- Clinical efficacy of Entoban - Ph.D. Gavrilova L.A. - Lugansk, Ukraine 2010
- Evaluation of the effectiveness of the drug "Entoban" in the treatment of patients with acute intestinal amoebiasis (inaccessible link)