Chronic cerebrospinal venous insufficiency (HCCVN), chronic cerebro-spinal venous insufficiency, CCSVI ) is a syndrome in which a venous outflow from the central nervous system is impaired. There is a hypothesis that this syndrome plays a significant role in the pathogenesis of multiple sclerosis . The appearance of this hypothesis provoked optimism in patients with multiple sclerosis, but it remains an unrecognized medical community because it has not yet received confirmation or refutation in randomized controlled clinical trials. [one]
History
Chronic cerebrospinal venous insufficiency syndrome was first described by Italian vascular surgeon Paolo Zamboni in 2008 and published in 2009. [2] According to Dzamboni, stenosis of the jugular and unpaired veins is observed with HCCVS syndrome, which leads to a decrease in blood flow in them and intermittent return movement of blood (reflux). Violation of venous hemodynamics in large veins leads to hemodynamic disorders in the venules of the central nervous system and changes in the blood-brain barrier , which are pathogenetic for the development of multiple sclerosis.
In 2009, the first international symposium on this issue, organized by the International Union of Phlebologists, was held in Bologna (Italy).
Notes
- ↑ Qiu J (May 2010). "Venous abnormalities and multiple sclerosis: another breakthrough claim?". Lancet Neurol 9 (5): 464–5.
- ↑ Zamboni P, Galeotti R, Menegatti E, et al. (April 2009). "Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis." J. Neurol. Neurosurg. Psychiatr. 80 (4): 392–9.
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