Kyotrophin (L-tyrosyl-L-arginine) is a neuroactive dipeptide involved in the regulation of brain pain. It was first isolated in the bovine brain by Japanese scientists in 1979 [1] . Kyotrophin was named after the place of its discovery - Kyoto, and because in its analgesic effect it resembled morphine . Kyotrophin has an analgesic effect, but it does not affect opioid receptors. Its action is based on the secretion of endorphin and its protection from decay. It also has the properties of a neurotransmitter / neuromodulator . Kyotrophin has been shown to be found in human cerebrospinal fluid , and in patients suffering from constant pain, its content is lower [2] .
| Kyotrophin | |
|---|---|
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| Are common | |
| Systematic name | (2 S ) -2 - [[(2 S ) -2-Amino-3- (4-hydroxyphenyl) propanoyl] amino] -5- (diaminomethylideneamino) pentanoic acid |
| Chem. formula | C 15 H 23 N 5 O 4 |
| Physical properties | |
| Molar mass | 337.374 g / mol |
| Classification | |
| Reg. CAS number | 70904-56-2 |
| PubChem | |
| Smiles | |
| Inchi | |
| Chebi | |
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Notes
- ↑ Takagi, Shiomi, Ueda et al., 1979 .
- ↑ Nishimura, Kaya, Hazato et al., 1991 .
Literature
- H Takagi, H Shiomi, H Ueda et al. A novel analgesic dipeptide from bovine brain is a possible Met-enkephalin releaser // Nature / P. Campbell - Nature Publishing Group , 1979. - Vol. 282, Iss. 5737. - P. 410–2. - ISSN 1476-4687 ; 0028-0836 - doi: 10.1038 / 282410A0 - PMID: 228202
- K Nishimura, K Kaya, T Hazato et al. [Kyotorphin like substance in human cerebrospinal fluid of patients with persistent pain] // Masui. The Japanese journal of anesthesiology - 1991.- T. 40, no. 11. - S. 1686–90. - ISSN 0021-4892 - PMID: 1766121