Rac2 ( eng. Ras-related C3 botulinum toxin substrate 2 ) - cytosolic protein , Rho GTPase from the GTPase superfamily, belongs to the "small" G-proteins . It is in two states: active GTP- bonded and inactive GDF- bonded state. In its active form, it binds in the cell with a variety of effector proteins and leads to the regulation of many cellular processes, such as secretion , phagocytosis of apoptotic cells, polarization of epithelial cells and the formation of membrane folds and outgrowths ( eng. Membrane ruffles ). Participates in the activation of NADPH oxidase NOX2 .
| Rac2 (Ras-related C3 botulinum toxin substrate 2) | |
|---|---|
| Designations | |
| Characters | Rac2 ; EN-7 |
| Entrez gene | 5880 |
| Hgnc | 9802 |
| OMIM | 602049 |
| Refseq | NM_002872 |
| UniProt | P15153 |
| Other data | |
| Locus | 22nd hr. , 22q13.1 |
Opened and described for the first time in 1989, by analogy with Rac1 .
Structure
The mature form of the protein, formed after cleavage of the C-terminal tripeptide, consists of 189 amino acids.
Bibliography
- Beckers CM, van Hinsbergh VW, van Nieuw Amerongen GP regulates barrier resistance (Eng.) // Thrombosis and Haemostasis : journal. - 2010. - January ( vol. 103 , no. 1 ). - P. 40-55 . - DOI : 10.1160 / TH09-06-0403 . - PMID 20062930 .