Micrococcal nuclease is an enzyme whose main property is the ability to break the primary structure of nucleic acids, in particular DNA , in the areas between nucleosomes .
In other words, micrococcal nuclease separates the nucleosomes from each other, destroying the portion of DNA connecting them, but without affecting the portion of DNA directly associated with histone proteins .
Micrococcal nuclease preparations are used in molecular biology to study chromosomal DNA molecules.
Literature
- Molecular biology. The structure and biosynthesis of nucleic acids: - Moscow, "Higher School", 1990, under the editorship of A. S. Spirin. ISBN 5060000869