Complete synthesis - in organic chemistry, complete laboratory synthesis of a complex molecule from simple and affordable chemical compounds. The traditional objects of complete synthesis are substances with a complex structure, obtained from natural sources.
The first example of complete synthesis is the urea synthesis carried out in 1828 by Wöhler .
In different years, complete syntheses of such natural compounds as cholesterol , reserpine , colchicine , vitamin B 12 , prostaglandins and many others were carried out.
Advances in the field of complete syntheses have been repeatedly awarded the Nobel Prize in chemistry . In 1965, Robert Woodward became the prize winner. In 1990, Elias James Cory was awarded the prize.