Chloride channel 7 ( English chloride channel 7, CLC-7, CLCN7 ) - a potential-dependent chloride channel - an antiporter from the CLCN superfamily. It exchanges ions of chlorine and hydrogen, which leads to acidification of the lysosome medium. Identified in 1995.
| Chloride Channel 7 | |||||||||||||
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| Symbol | ; CLC-7; CLC7; FLJ26686; FLJ39644; FLJ46423; OPTA2 | ||||||||||||
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Structure
The molecule of this chloride channel consists of 805 amino acids (molecular weight 88.679 kDa) and 10 transmembrane fragments. Thus, both terminal domains are in the cytosol. According to the amino acid sequence of all chloride channels, the closest to the chloride channel is 6 - 45% homology.
Pathology
Disorders of the CLCN7 gene are known to lead to autosomal recessive osteopetrosis type 4 ( pediatric malignant osteopetrosis type 2 ) and to autosomal dominant osteoprosis type 2 ( Albers-Schonberg disease ). Diseases among other disorders are characterized by increased bone density.
Links
- Brandt S., Jentsch TJ ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family. (Eng.) // FEBS Letters : journal. - 1996. - Vol. 377 , no. 1 . - P. 15-20 . - DOI : 10.1016 / 0014-5793 (95) 01298-2 . - PMID 8543009 .
- Héon E., Piguet B., Munier F., et al. Linkage of autosomal dominant radial drusen (malattia leventinese) to chromosome 2p16-21. (English) // JAMA Ophthalmology : journal. - 1996. - Vol. 114 , no. 2 . - P. 193-198 . - PMID 8573024 .
- Lennon G., Auffray C., Polymeropoulos M., Soares MB The IMAGE Consortium: an integrated molecular analysis of genomes and their expression. (English) // Genomics : journal. - Academic Press , 1996. - Vol. 33 , no. 1 . - P. 151-152 . - DOI : 10.1006 / geno.1996.0177 . - PMID 8617505 .