Inducible nitric oxide synthase ( induced by NO-synthase ) is a group of human NO-synthases produced by hepatocytes .
| Induced synthase nitric oxide |
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| Available structures |
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| PDB | Search for orthologs: PDBe , RCSB |
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| Identifiers |
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| Symbol | ; Hep-nos; INOS; Nos; NOS2A |
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| External id | ChEMBL : GeneCards : |
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| Sources: Amigo / QuickGO |
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It is encoded by genes on the 17th chromosome . Alternative splicing generates two transcripts producing different enzyme isoforms. The NOS2 enzyme has been known since 1992 , [1] and in 1995 , when its gene was described and the existence of three pseudogenes was discovered: NOS2P1 (NOS2A), NOS2P2 (NOS2B), NOS2P3 (NOS2C). [2] The enzyme synthesis is induced by a combination of lipopolysaccharide and certain cytokines .
