Keratin 12 is one of human keratins encoded by the KRT12 gene on the 17th chromosome . Keratin 12 is significantly expressed in the corneal epithelium and is believed to play an important role in the functioning of this layer.
| Keratin 12 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbol | ; K12 | ||||||||||||
| External id | GeneCards : | ||||||||||||
| |||||||||||||
| Ortologists | |||||||||||||
| View | Person | Mouse | |||||||||||
| Entrez | |||||||||||||
| Ensembl | |||||||||||||
| UniProt | |||||||||||||
| RefSeq (mRNA) | |||||||||||||
| RefSeq (protein) | |||||||||||||
| Locus (UCSC) | |||||||||||||
| PubMed Search | |||||||||||||
For keratins, the formation of heterodimer pairs is typical, and keratin 12, according to research, is combined into such pairs with keratin 3 in the cornea of many species.
Content
Animal Studies
Mice homozygous for the KRT12 gene have a fragile corneal epithelium that peels off under friction. [one]
Medical value
Mutations of the KRT12 and KRT3 genes are associated with Mesmann's corneal dystrophy .
See also
- Keratin Diseases
- Keratins
- Keratin 3
Notes
- ↑ Kao, WW-Y .; Liu, C.-Y .; Converse, RL; Shiraishi, A .; Kao, CW-C .; Ishizaki, M .; Doetschman, T .; Duffy, J.: Keratin 12-deficient mice have fragile corneal epithelia. Invest. Ophthal. Vis. Sci. 37: 2572-2584, 1996.