Minisatellites are repeating DNA fragments from 9-10 or more (usually up to 100 [1] ) nucleotides in length [2] . Used as DNA markers. The mechanisms of origin are slippage during DNA replication, point mutations, and recombination .
Structure
Minisatellites consist of repeating monomers, mainly from guanine - cytosine variants, ranging in length from 10 to 100 base pairs. These repetitive variants are sequentially mixed, which makes them ideal companions for studying the mechanisms of DNA twisting.
Minisatellites differ from microsatellites in the length of the monomer, as well as localization in the genome. Minisatellites, unlike microsatellites, can be localized in the subtelomeric (for example, in humans) and pericentromeric (for example, in Arabidopsis thaliana ) regions of the chromosomes. They differ from satellite DNA in a smaller number of repeating monomers and, therefore, a shorter length of the field of tandem repeats formed [2] .
See also
- Microsatellites
- Mobile genetic elements
- Transposon
Notes
- ↑ Hemleben V., Beridze T. G., Bachman L., Kovarik Y., Torres R. Satellite DNA // Successes in Biological Chemistry. - 2003.- T. 43 . - S. 267-306 . Archived on May 18, 2015.
- ↑ 1 2 López-Flores I., Garrido-Ramos MA The repetitive DNA content of eukaryotic genomes // Garrido-Ramos MA Genome Dynamics. - 2012 .-- T. 7 . - S. 1-28 . - ISBN 978-3-318-02149-3 . - DOI : 10.1159 / isbn.978-3-318-02150-9 .