Plasmin

Plasmin is a human protein formed from the circulating proenzyme of plasminogen encoded by the PLG gene on the 6th chromosome . Plasmin belongs to the family of serine proteases and causes the breakdown of many proteins, but its most important function is the destruction of fibrin clots. In turn, angiostatin , an inhibitor of angiogenesis , is formed from plasmin under certain conditions.

Plasmin
Available Structures PDB Search: PDB ID List
Identifiers
	Plg, plasminogen, plasmin
External IDs
Gene ontology Functions Cell component Biological process Sources: Amigo / QuickGO
RNA expression profile
Orthologists
Kinds	Person	Mouse
Entrez
Ensembl
Uniprot
RefSeq (mRNA)
RefSeq (protein)
Locus (UCSC)
PubMed Search
Wikidata
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Cutting off part of plasminogen causing plasmin formation is activated by urokinase and tissue plasminogen activator . These molecules are also synthesized in the body as proenzymes. There are also “external” plasmin formation activators - streptokinase and staphylokinase produced by bacteria.

Plasmin contains five similar structural sequences, called “ kringle domains ” for their special shape ( dates. Kringle is a type of pretzel that is popular in Scandinavian countries). In Russian-language literature, they are called double loop and kringle domains. This type of domain is also found in other proteins.