Nitric oxide synthase 1 , neuronal nitric oxide synthase is a human enzyme encoded by the NOS1 gene on the 12th chromosome . Contrary to the name, this form of NO synthase is expressed not only in the brain , but also in the muscles.
| Nitric oxide synthase 1 (neuronal) | |||||||||||||
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| Symbol | ; IHPS1; N-NOS; NC-NOS; NOS bNOS; nNOS | ||||||||||||
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Content
Clinical Importance
The possible role of NOS1 in asthma, [2] [3] schizophrenia [4] [5], and restless legs syndrome is noted. [6]
The predisposition to hypertrophic pyloric stenosis of newborns ( OMIM 179010 ) is significantly associated with variations in the NOS1 gene. [7]
See also
- NOS1AP - adapter protein of neuronal NO synthase
Notes
- ↑
- ↑ Grasemann H., Yandava CN, Drazen JM Neuronal NO synthase (NOS1) is a major candidate gene for asthma (English) // Clinical & Experimental Allergy : journal. - 1999 .-- December ( vol. 29 Suppl 4 ). - P. 39-41 . - PMID 10641565 . (inaccessible link)
- ↑ Leung TF, Liu EK, Tang NL, Ko FW, Li CY, Lam CW, Wong GW Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children (English) // Clinical & Experimental Allergy : journal. - 2005 .-- October ( vol. 35 , no. 10 ). - P. 1288-1294 . - DOI : 10.1111 / j.1365-2222.2005.02342.x . - PMID 16238787 .
- ↑ Shinkai T., Ohmori O., Hori H., Nakamura J. Allelic association of the neuronal nitric oxide synthase (NOS1) gene with schizophrenia (Eng.) // Molecular Psychiatry : journal. - 2002. - Vol. 7 , no. 6 . - P. 560-563 . - DOI : 10.1038 / sj.mp.4001041 . - PMID 12140778 .
- ↑ Reif A., Herterich S., Strobel A., Ehlis AC, Saur D., Jacob CP, Wienker T., Töpner T., Fritzen S., Walter U., Schmitt A., Fallgatter AJ, Lesch KP A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function (Eng.) // Molecular Psychiatry : journal. - 2006 .-- March ( vol. 11 , no. 3 ). - P. 286-300 . - DOI : 10.1038 / sj.mp.4001779 . - PMID 16389274 .
- ↑ Winkelmann J., Lichtner P., Schormair B., Uhr M., Hauk S., Stiasny-Kolster K., Trenkwalder C., Paulus W., Peglau I., Eisensehr I., Illig T., Wichmann HE, Pfister H., Golic J., Bettecken T., Pütz B., Holsboer F., Meitinger T., Müller-Myhsok B. Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome .) // Movement Disorders : journal. - 2008 .-- February ( vol. 23 , no. 3 ). - P. 350—358 . - DOI : 10.1002 / mds.21647 . - PMID 18058820 .
- ↑ Saur, D .; Vanderwinden, J.-M .; Seidler, B .; Schmid, RM; De Laet, M.-H .; Allescher, H.-D.: Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis. Proc. Nat. Acad. Sci. 101: 1662-1667, 2004. PMID 14757827
Links
- nNOS (NO synthase neuronal, type I) - medicalbiol.ru