Atsizol

Atsizol ( bis- (1-vinylimidazole) zinc diacetate ) - Russian drug, antidote against carbon monoxide . Along with the therapeutic, the presence of a preventive action is stated: it can be taken 20-30 minutes before entering the lesion.

Developed at the Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences in the 1990s. ^[one]

Included in the Russian Vital and Essential Drugs List in ATC code V03A ^[2] . Included in the first- aid kit individual AI-4 .

According to the 2016, science does not know reliable antidotes for use in case of carbon monoxide poisoning ^[3] .

Content

Pharmacological properties

Pharmacodynamics

Atsizol prevents the formation of carboxyhemoglobin due to the effect on the cooperative interaction of hemoglobin subunits , as a result of which the relative affinity of hemoglobin for carbon monoxide decreases, oxygen binding (reduction of the Hill constant) and gas transmission properties of blood are improved. Atsizol reduces the severity of intoxication when carbon monoxide poisoning in terms of the severity of metabolic acidosis, accelerates the elimination of carbon monoxide (CO) from the body. The drug reduces the body's need for oxygen, helps to increase the resistance to hypoxia of the organs most sensitive to oxygen deficiency: brain, myocardium, liver, etc.

Atsizol is a complex organozinc compound and compensates for zinc deficiency in the body.

Pharmacokinetics

The maximum concentration of alzola in the blood is reached 20-30 minutes after intramuscular injection of 1 ml (60 mg) of the drug and stored in the blood plasma for 4-5 hours. The half-life is 1-1.5 hours. It is mainly metabolized by the liver.

Indications for use

Atsizol is used as a prophylactic agent with the threat of poisoning and a therapeutic agent for poisoning of varying severity with carbon monoxide (CO) and other thermo-oxidative degradation products.

For preventive purposes, the drug is administered in a dose of 1 ml intramuscularly 20-30 minutes before entering the smoke zone (gas), with a high risk of inhalation of CO, during the period of work to eliminate the extinguishing of the fires and rescue the victims. The protective effect lasts for 1.5-2 hours. Repeated use of the drug is allowed 1 hour after the first injection. For therapeutic purposes, Acizol is recommended to be used as soon as possible after poisoning, regardless of the severity of the lesion. The drug is administered in a dose of 1 ml intramuscularly immediately after removal of the victim from the fire zone (gassed room). Repeated administration is allowed 1 hour after the first injection.

Contraindications

Individual intolerance to the components of the drug. Other contraindications have been identified.

Dosage and Administration

For prophylactic purposes, 1 ml of Arizola solution is injected intramuscularly with the threat of poisoning 20-30 minutes before the intended exposure to CO and thermal decomposition products. Repeated administration is allowed 1 hour after the first injection of the drug.

As a remedy, Acizol is recommended to be used as soon as possible after the poisoning, regardless of the severity of the lesion. The drug is administered in a dose of 1 ml intramuscularly immediately after removal of the victim from the fire zone (gassed room). Subsequently, Atsizol is administered intramuscularly 1 ml 2-4 times a day.

The maximum daily dose for an adult is 240 mg (4 ml).

The course of treatment is on average 7-10 days.

Overdose

Metallic taste in the mouth, headache, nausea. These phenomena disappear after drug withdrawal.

Side Effects

Adverse effects have been identified. In some cases, possible moderate pain at the injection site.

Interaction with other drugs

Not recommended for use with unithiol . When prescribing with other drugs, no negative effects were noted.

Release form

Solution for intramuscular administration of 60 mg / ml.

On 1 ml of solution in an ampoule on 1 or 5 ampoules in a blister strip packaging from a film of polyvinyl chloride. On 1 or 2 blister packs on 5 ampoules together with the instruction for application and a knife for opening of ampoules place in a pack from a cardboard. When using ampoules with a dot or ring, the knife is not inserted.

For hospitals: 50 or 100 blister packs of 5 ampoules, together with instructions for use and a knife for opening ampoules are placed in a cardboard box. When using ampoules with a dot or ring, the knife is not inserted. The number of copies of the instructions should correspond to the number of blister packs.

For the formation of special purpose kits: 50 or 100 blister packs of 1 ampoule, along with instructions for medical use and knives for opening ampoules are placed in a cardboard box. When using ampoules with a dot or ring, the knife is not inserted. The number of copies of the instructions should correspond to the number of blister packs.

Also produced capsules of 10 pieces. in the package (1 capsule 120mg zinc bis diacetate)

Storage Conditions

List B. In the dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children. Shelf life 3 years. Do not use after the period indicated on the package. Pharmacy Sale Terms Without Prescription

Notes

↑ "Science in Siberia"
↑ https://pharmvestnik.ru/articles/kapsula-zhizni-prnt-19-m4-925.html
Ient Scientists poisoning carbon monoxide poisoning antidote (Eng.) , Associated Press (Dec 09, 2016). The appeal date was September 29, 2018. "we’re not poisoning," it’s the most common poisoning.

Links

[1] "Science in Siberia"

[2] ttps://pharmvestnik.ru/articles/kapsula-zhizni-prnt-19-m4-925.html

[3] Ient Scientists poisoning carbon monoxide poisoning antidote (Eng.) , Associated Press (Dec 09, 2016). The appeal date was September 29, 2018. "we’re not poisoning," it’s the most common poisoning.