Oxalate nephropathy is a kidney damage caused by metabolic disorders and the deposition of oxalic acid salts in the kidneys and other internal organs . It is a consequence of hyperoxaluria .
| Oxalate Nephropathy | |
|---|---|
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| ICD-10 | E 74.8 |
| ICD-9 | 271.8 |
| Diseasesdb | |
| eMedicine | med / 3027 |
| Mesh | D006959 |
Primary hyperoxaluria ( lat. Hyperoxaluria ), or oxalosis , is a rare hereditary disease that occurs in children aged 1β4 years.
Recessive fermentopathy , a fatal metabolic defect caused by a deficiency of enzymes involved in the exchange of glyoxylic acid ( CHO-COOH ).
Primary hyperoxaluria represents two diseases inherited in an autosomal recessive manner :
- Type 1 is due to a deficiency of the peroxisomal enzyme alanine: glycoxylate aminotransferase .
- 2nd type: lack of the cytoplasmic glycoxylate reductase enzyme .
Primary hyperoxaluria is characterized by the accumulation in the body of excess amounts of oxalic acid , which enters the bloodstream and is excreted through the kidneys with urine , where its concentration reaches a high level. Under physiological pH values ββin the kidneys, oxalic acid combines with calcium to form an insoluble salt , the crystals of which are gradually deposited in the kidney tissue, which ultimately leads to the development of renal failure .