The epidermal growth factor receptor (EGFR, ErbB-1) is a transmembrane receptor that binds extracellular ligands from the epidermal growth factor group. It belongs to the ErbB receptor family, in particular to the tyrosine kinase receptor subfamily (possessing internal tyrosine kinase activity): EGFR (ErbB-1), HER2 / c-neu ( ErbB-2 ), Her 3 ( ErbB-3 ) and Her 4 ( ErbB- 4 ). Mutations of the receptor, leading to overexpression or increased activity, can cause cancer.
Epidermal Growth Factor Receptor | |
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Legend | |
Characters | EGFR ; ERBB1 |
Entrez gene | 1956 |
Hgnc | 3236 |
OMIM | 131550 |
Refseq | NM_005228 |
UniProt | Q9GZX1 |
Other data | |
Locus | 7th hr. , 7p12 |