A photosensitizer is a natural or artificially synthesized substance capable of photosensitizing biological tissues, that is, increasing their sensitivity to light.
Content
- 1 Medical Applications
- 1.1 Applicable or developed for medicine photosensitizers
- 2 Photosensitivity as a side effect of drugs and plants
- 3 notes
- 4 See also
Medical use
In a narrow sense, talking about photosensitizers, they mean a class of substances - derivatives of porphyrins and related heteroaromatic structures - developed as drugs for photodynamic therapy (PDT) and fluorescence diagnostics of malignant tumors, trophic ulcers and some other pathologies.
Ideally, photosensitizers should selectively accumulate in tumors and hardly remain in the surrounding healthy tissues. When illuminating a tissue with an accumulated photosensitizer, the molecules of the latter act as a kind of converters that can transfer the energy of light quanta to oxygen in the bloodstream and tissues, turning it into an active singlet form and highly active oxygen-containing radicals, which, in fact, have a cytotoxic effect, causing damage tumor vascular system or necrosis or apoptosis of abnormal cells.
Photosensitizers used or developed for medicine
Photosensitizers developed, undergoing clinical trials or admitted to the clinic in various countries include:
Derivatives of Ξ΄-aminolevulinic acid (a precursor of endogenously formed protoporphyrin IX photosensitizer)
- Alasens [1]
Benzoporfin derivatives
- Vizudin [2]
Hematoporphyrin derivatives
- Photofrin [3]
- Photohem [4]
Derivatives of chlorin e6
- Photolon [5]
- Radachlorin [6]
- Photoditazine [7]
Derivatives of bacteriochlorophylls
- Tukad (TOOKAD, WST11) [8]
Phthalocyanine derivatives
- Photosens [9]
Photosensitivity as a side effect of drugs and plant
Notes
- β Articles on Alasens and its analogues in the PubMed database.
- β Articles on "Vizudin" in the PubMed database.
- β Articles on Photofrin in the PubMed database.
- β Articles on the "Photohem" in the PubMed database.
- β Articles "Photolon" in the database PubMed database.
- β Articles on βRadachlorinβ in the PubMed database.
- β Articles on βPhotoditazineβ in the PubMed database.
- β Articles on Tukad in the PubMed database.
- β Photosense articles in the PubMed database .
See also
- Photodermatosis
- Hogweed of Sosnowski
- Phototoxicity
- photosensitization