LIN28 homolog A [1] is a gene found in animal genomes [2] . In the human genome , it is located on the first chromosome , at the locus 1p36.11 [3] .
| Lin-28 homolog A (C. elegans) | |||||||||||||
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 PDB rendering based on 2cqf. | |||||||||||||
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| Symbol | ; CSDD1; LIN-28; LIN28; ZCCHC1; lin-28A | ||||||||||||
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LIN28 encodes an RNA- binding protein containing a cold shock domain in the N-terminal part and two motifs of zinc fingers of the CCHC retroviral type in the C-terminal region [4] .
The protein is a marker of undifferentiated human embryonic stem cells [5] and is used to increase the efficiency of stem cell production from fibroblasts [6] . It was shown that LIN28 protein binds to the Let7 microRNA precursor and blocks the formation of mature Let7 miRNAs in mouse embryonic stem cells [7] .
Notes
- ↑ LIN28A Symbol Report | HUGO Gene Nomenclature Committee . www.genenames.org. Date of treatment August 6, 2018.
- ↑ HR Horvitz, PW Sternberg, IS Greenwald, W. Fixsen, HM Ellis. Mutations that affect neural cell lineages and cell fates during the development of the nematode Caenorhabditis elegans // Cold Spring Harbor Symposia on Quantitative Biology. - 1983 .-- T. 48 Pt 2 . - S. 453-463 . - ISSN 0091-7451 .
- ↑ LIN28A lin-28 homolog A [Homo sapiens (human) - Gene - NCBI] (eng.) . www.ncbi.nlm.nih.gov. Date of appeal September 22, 2018.
- ↑ Eric G. Moss, Lingjuan Tang. Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites // Developmental Biology. - 2003-06-15. - T. 258 , no. 2 . - S. 432–442 . - ISSN 0012-1606 .
- ↑ Mark Richards, Siew-Peng Tan, Jee-Hian Tan, Woon-Khiong Chan, Ariff Bongso. The transcriptome profile of human embryonic stem cells as defined by SAGE // Stem Cells (Dayton, Ohio). - 2004. - T. 22 , no. 1 . - S. 51–64 . - ISSN 1066-5099 . - DOI : 10.1634 / stemcells.22-1-51 .
- ↑ Junying Yu, Maxim A. Vodyanik, Kim Smuga-Otto, Jessica Antosiewicz-Bourget, Jennifer L. Frane. Induced pluripotent stem cell lines derived from human somatic cells // Science (New York, NY). - 2007-12-21. - T. 318 , no. 5858 . - S. 1917-1920 . - ISSN 1095-9203 . - DOI : 10.1126 / science.1151526 .
- ↑ Srinivas R. Viswanathan, George Q. Daley, Richard I. Gregory. Selective blockade of microRNA processing by Lin28 // Science (New York, NY). - 2008-04-04. - T. 320 , no. 5872 . - S. 97-100 . - ISSN 1095-9203 . - DOI : 10.1126 / science.1154040 .
Literature
- Shyh-Chang N, Daley GQ. (2013) Lin28: primal regulator of growth and metabolism in stem cells . Cell Stem Cell. ; 12 (4): 395-406. doi: 10.1016 / j.stem.2013.03.03.005.
- Mayr F, Heinemann U. (2013) Mechanisms of Lin28-mediated miRNA and mRNA regulation - a structural and functional perspective. Int J Mol Sci. 14 (8): 16532-53. doi: 10.3390 / ijms140816532.
- Ng Shyh-Chang, Hao Zhu, T. Yvanka de Soysa, Gen Shinoda, Marc T. Seligson, Kaloyan M. Tsanov, Liem Nguyen, John M. Asara, Lewis C. Cantley, George Q. Daley. (2013) Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism. Cell ,; 155 (4): 778 DOI: 10.1016 / j.cell.2013.09.09.059