Phenoxymethylpenicillin

Pharmacological properties. The drug has an antibacterial effect by inhibiting the process of division of bacteria, which leads to their death. Phenoxymethylpenicillin is well and rapidly absorbed in the digestive tract. Therapeutic concentrations of the drug in the blood are created after 30 minutes and persist for 6 to 8 hours. Penetrates through the placental barrier and passes into breast milk. It is excreted mainly in the urine.

It is used to treat infectious diseases caused by microorganisms sensitive to phenoxymethylpenicillin, including diseases such as exacerbation of chronic bronchitis, pneumonia, tonsillitis and chronic tonsillitis , otitis media , skin and soft tissue diseases ( erysipelas , streptoderma and pyoderma ); infectious diseases: gonorrhea , syphilis , tetanus , anthrax . It is one of the main drugs for the prevention of complications of tonsillitis and chronic tonsillitis, in particular acute rheumatic fever, small chorea, bacterial endocarditis, glomerulonephritis. It is used for diphtheria carriage, as well as for the prevention of bacterial endocarditis after minor surgical interventions (tooth extraction, tonsil removal ). ^[one]

Phenoxymethylpenicillin is contraindicated in case of hypersensitivity to penicillins, cephalosporins, carbapenems , in case of malabsorption from the digestive tract. Severe gastrointestinal diseases, accompanied by vomiting and diarrhea.

Use the drug with caution in patients with allergic diathesis and bronchial asthma. During pregnancy and during breastfeeding, you can take Phenoxymethylpenicillin, but before starting treatment, the expected benefits of its use for the mother and the potential risk to the fetus or child should be carefully weighed. In renal failure, it is necessary to reduce the dose or increase the interval between doses. In patients with an allergic reaction to cephalosporin antibiotics ( cephalexin , cefazolin , ceftriaxone , cefotaxime , etc.), a cross allergy to Phenoxymethylpenicillin may occur.

If you are taking any other medicines, be sure to inform your doctor. Drinking soda (sodium bicarbonate) reduces the absorption of phenoxymethylpenicillin in the intestines. The combined use with a number of other antibacterial drugs, such as sulfadimethoxin , biseptol cotrimoxazole , tetracycline , doxycycline , chloramphenicol , erythromycin , mutually reduces the effectiveness of these drugs. With the simultaneous use of phenoxymethylpenicillin with hormonal contraceptives, the effectiveness of the latter decreases. Acetylsalicylic acid and indomethacin slow down the elimination of phenoxymethylpenicillin by the kidneys and thus lengthen its effect in the patient's body.

With long-term use of phenoxymethylpenicillin, it is necessary to periodically do blood tests and evaluate the functional state of the kidneys.

Phenoxymethylpenicillin is taken orally on an empty stomach, 30-60 minutes before, or 2 hours after a meal. For dosage for children, consult your doctor. Adults take 2 to 3 tablets (0.5 - 0.75 g) 3-4 times a day, the maximum daily dose is 16 tablets (4.0 g). Duration of treatment - at least 5-7 days; with infections caused by β-hemolytic streptococcus , 7-10 days.

To prevent relapse of rheumatic fever and / or small chorea, take 2 tablets (0.5 g) 2 times a day.

Regarding dosage when used to prevent streptococcal infections and prevent endocarditis after minor surgical interventions, you should consult your doctor.

Phenoxymethylpenicillin is a fairly safe drug, well tolerated by patients. But, sometimes diarrhea, mild nausea, inflammation of the tongue and gums, headache, and in some cases skin manifestations of allergies ( itching , rashes , redness ) are possible. With the appearance of these and other adverse reactions, stop using the drug and consult a doctor immediately!

Shelf life. 4 years.

It is forbidden to use the medicine after the expiration date indicated on the package.

Visual signs of the unsuitability of the drug: discoloration of the tablets (normally white).

Store in a dry, dark place at a temperature of 15 ° C to 25 ° C. Keep out of the reach of children.

On prescription.

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