S-cells are endocrine cells of the small intestine mucosa that secrete secretin .
S-cells belong to apudocytes and are part of the gastroenteropancreatic endocrine system , which is part of the diffuse endocrine system (synonymous with APUD system ).
Localization
S-cells are mainly located in the mucous membrane of the duodenum and in the proximal jejunum . In much smaller amounts, S cells are present in the distal part of the small intestine. [one]
Functions
The main function of S cells is the secretion of the polypeptide pro- secretin , an inactive precursor of secretin, which is converted into secretin by the action of hydrochloric acid in gastric juice . Hydrochloric acid begins to play a stimulating role at pH <4. Fatty acids , ethanol , and spice components also stimulate secretin production. Stimulate the production of secretin bile acids . [one]
S-cells are one of the few endocrine cells that are insensitive to gastrin-releasing peptide .
Notes
- β 1 2 Mayev I.V., Samsonov A.A. Diseases of the duodenum. M., MEDpress-inform, 2005, - 512 s, ISBN 5-98322-092-6 .