Lithium oxybate (lithium oxybutyrate, Lithii oxybutyras). Lithium gamma hydroxybutyrate.
| Lithium oxybutyrate | |
|---|---|
| Chemical compound | |
| Gross formula | C 4 H 7 LiO 3 |
| Cas | |
| PubChem | |
| Classification | |
| ATX | |
| Other names | |
| Lithium Oxybate, Lithium Oxybutyrate, Lithium Gamma Oxybutyrate | |
Content
General Information
The chemical structure is a lithium analogue of sodium oxybutyrate .
The therapeutic effect of the drug is mainly associated with the presence of lithium ion in its molecule, however, the drug also has elements of the activity characteristic of sodium oxybutyrate, it has a sedative effect. Compared to lithium carbonate, oxybutyrate is less toxic and more active. Lithium oxybutyrate can be administered intramuscularly.
Indications for use are basically the same as for lithium carbonate: hypomanic and manic states and the prevention of attacks of affective disorders. The drug is also used for psychopathy, neurosis, organic and other diseases with recurrent affective disorders.
Prescribe lithium oxybutyrate orally (after eating) or intramuscularly. A single dose - starting from 0.5-1 g, daily - up to 3 g (in 2-3 doses). With severe psychomotor agitation or patient refusal to take the drug inside it is administered intramuscularly.
When used as a preventive measure, they start with a dose of 0.5 g.
Lithium oxybutyrate is also prescribed as an antihypoxic agent. There is evidence of the antiarrhythmic effect of the drug, as well as the use of lithium carbonate for the correction of neutropenia in radiation treatment of patients with lymphogranulomatosis . The drug was found to cause a true increase in granulocyte production.
Contraindications
In all cases of the use of lithium oxybutyrate, all safety precautions must be observed and the contraindications provided for other lithium-containing preparations should be taken into account (see lithium preparations ). Therapy of lithium with oxybate is also contraindicated in case of atrioventricular block , intraventricular block, gastric ulcer and 12 duodenal ulcer in the acute stage, cataract [1] .
Physical Properties
Crystal powder, white or white with a barely noticeable creamy tint. Easily soluble in water, difficult in alcohol; pH of a 20% aqueous solution of 8.5-9.5.
Release form
Method of release: tablets of 0.5 g; 20% solution in ampoules of 2 ml (0.4 g in ampoule).
Notes
- ↑ Reference guide for psychopharmacological and antiepileptic drugs approved for use in Russia / Ed. S. N. Mosolova. - Ed. 2nd, rev. - M .: "BINOM Publishing House", 2004. - S. 111. - 304 p. - 7000 copies. - ISBN 5-9518-0093-5 .