Periciazin ( lat. Periciazinum ) - an antipsychotic agent , belongs to the group of piperidine derivatives of phenothiazine [1] . This group of drugs has less potent antipsychotic activity than aliphatic and piperazine derivatives of phenothiazine [2] .
| Periciazine | |
|---|---|
| Periciazinum | |
 | |
| Chemical compound | |
| IUPAC | 10- [3- (4-hydroxy-1-piperidinyl) propyl] -10H-phenothiazine-2-carbonitrile |
| Gross formula | C 21 H 23 N 3 OS |
| Molar mass | 365.49 g / mol |
| Cas | |
| PubChem | |
| Drugbank | |
| Classification | |
| ATX | |
| Dosage Forms | |
| 10 mg capsules | |
| Other names | |
| "Neuleptil" | |
Trade name: "Neuleptyl" .
Content
General Information
Like other antipsychotics, pericyazine potentiates the effects of drugs, sleeping pills and analgesics . It has adrenolytic and relatively strong anticholinergic activity; has a strong antiemetic effect [2] .
The antipsychotic effect of periciazine is combined with a sedative without a stimulating component [2] .
The drug is indicated in the treatment of patients with both psychotic and psychopathic conditions. It is especially effective for behavioral disorders (especially in children), contact disorders. It reduces aggressiveness and, thanks to a milder sedation than chlorpromazine , does not cause severe lethargy, lethargy, and is well tolerated [2] .
Due to a more selective, than other antipsychotics, normalizing effect on behavior, periciazine is called in the literature βbehavior correctorβ [2] .
Prescribe periciazine orally after meals. The dose for adults is first 5-10 mg per day; then it is gradually increased (every 1β2 days by 10 mg) until the optimal effect is obtained [2] (usually up to 30β40 mg [2] , and in some cases up to 70β90 mg per day).
The daily dose is given in 2-3 doses: in the morning 1 / 4-1 / 3 of the daily dose, the rest - in the evening (due to the possible development of drowsiness) [2] .
Children and seniors are prescribed starting from 5 mg per day, then the dose is gradually increased to 10-20-30 mg per day. After obtaining a persistent effect, the dose of the drug is gradually reduced, selecting an individual maintenance dose [2] .
Side Effects
Depression, spasmodic torticollis , oculomotor crises, trismus , other extrapyramidal disorders , orthostatic hypotension , constipation, dry mouth [3] , urinary retention, accommodation paralysis, hyperthermia [2] , amenorrhea , impotence , galactorrhea , weight gain [3] , photosensitization , allergic reactions [4] , extremely rarely - cholestatic jaundice , agranulocytosis [3] .
Contraindications
A history of toxic agranulocytosis, a closed-angle form of glaucoma , porphyria , prostate disease [3] .
Precautions
With caution is prescribed for diseases of the liver, kidneys and cardiovascular system , as well as elderly patients. When prescribing periciazine to patients suffering from epilepsy (the drug can lower the threshold of convulsive readiness) and parkinsonism , especially careful medical supervision is necessary. If hyperthermia develops, periciazine should be discontinued [3] .
With caution, prescribe the drug to drivers and people working with mechanisms, because of the possibility of drowsiness, especially at the beginning of therapy. During the use of periciazine is prohibited to drink alcohol [3] .
Drug Interactions
It enhances the effect of antihypertensive and hypnotics , tranquilizers , painkillers [3] , drugs for general anesthesia , and alcohol - containing drugs. With the combination of periciazine with paroxetine , the effect of both drugs is enhanced. When combined with sedatives or hypnotics or with procarbazine , the sedation is enhanced [5] .
Notes
- β Danilov D.S. Modern classifications of antipsychotic drugs and their significance for clinical practice (current state of the issue and its prospects) // Review of Psychiatry and Medical Psychology named after V. M. Betkhereva. - 2010 .-- S. 36β42.
- β 1 2 3 4 5 6 7 8 9 10 Mashkovsky M. D. Medicines. - 16th ed., Rev., Rev. and add. - Moscow: New Wave, 2012 .-- 1216 p. - 5,000 copies. - ISBN 978-5-7864-0218-7 .
- β 1 2 3 4 5 6 7 Gubsky Yu. I., Shapovalova V.A., Kutko I.I., Shapovalov V.V. Medicines in psychopharmacology. - Kiev - Kharkov: Health - Torsing, 1997. - 288 p. - 20,000 copies. - ISBN 5-311-00922-5 , 966-7300-04-8.
- β Rational Pharmacotherapy in Psychiatric Practice: A Guide for Practitioners / Ed. ed. Yu. A. Alexandrovsky, N. G. Neznanov. - Moscow: Litterra, 2014 .-- 1080 s. - (Rational pharmacotherapy). - ISBN 978-5-4235-0134-1 .
- β Drug Interaction and Pharmacotherapy Effectiveness / L.V. Derimedved, I.M. Pertsev, E.V. Shuvanova, I.A. Zupanets, V.N. Khomenko; under the editorship of prof. I. M. Pertseva. - Kharkov: Publishing house "Megapolis", 2001. - 784 p. - 5,000 copies. - ISBN 996-96421-0-X.