Pufemid (Puphemidum). 3- (p-Isopropoxyphenyl) succinimide
| Pufemid | |
|---|---|
| Chemical compound | |
| Gross formula | C 13 H 15 NO 3 |
| Cas | |
| PubChem | |
Content
General Information
Like ethosuximide , it is a derivative of succinic acid imide . In structure, it differs from ethosuximide in that instead of methyl and ethyl at the nitrogen atom in position 3 it contains a para-substituted phenyl radical.
Like other drugs of this group ( succinimides ) it has anticonvulsant activity. It is used for epilepsy type petit mal, as well as for temporal lobe epilepsy.
Take orally before meals. Dose for adults - starting from 0.25 g 3 times a day; with insufficient effect, the dose is increased to 1.5 g per day. Children under the age of 7 are prescribed 0.125 g, older than 7 years - 0.25 g 3 times a day.
Pufemid can be used in combination with other antiepileptic drugs.
Possible side effects are nausea, insomnia. With nausea, it is recommended to take the drug 1-1.5 hours after eating, in case of sleep disturbance - no later than 3-4 hours before sleep.
Contraindications
The drug is contraindicated in acute diseases of the liver and kidneys, diseases of the hematopoietic system, with hyperkinesis, severe atherosclerosis.
Physical Properties
White powder with a slightly yellowish tint. It is practically insoluble in water. Soluble in alcohol.
Release form
Release form: tablets of 0.25 g in a package of 50 pieces.