Hans Günter Nöller ( German: Hans Günter Nöller ) - German ( Germany ) gastroenterologist , professor of pediatrics at the University of Heidelberg , Germany .
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Biography
Nöller is known for his active work in creating new diagnostic and therapeutic methods for acid-dependent diseases of the gastrointestinal tract (GIT). In history, he remained as the author of the "Nöller alkaline test", as a developer of pH metric radio capsules and as a gastroenterologist who performed a large number of studies using these radio capsules.
Nöller Alkaline Test
In honor of Nöller called "Nöller alkaline test." The test consists in the fact that 0.5 g of sodium bicarbonate (baking soda) dissolved in 30 ml of water is injected into the stomach through the mouth and the pH dynamics are recorded in the stomach using an acidogastrometer (device for intragastric pH meter ). [1] [2] As a result of the introduction of alkali in the stomach, a reaction of neutralization of hydrochloric acid occurs:
the pH level rises, and after the so-called alkaline time, it returns to its original level due to the secretion of hydrochloric acid in the stomach.
Criteria for assessing acid-forming gastric function in an alkaline test [3]
| Assessment of alkalizing function of the stomach | Alkaline time, min | |
| On an empty stomach | With stimulation | |
| A sharp increase in hydrochloric acid production | less than 10 | less than 5 |
| Increased hydrochloric acid production | 10-20 | 5-10 |
| Normal rate of acid formation | 20-25 | 10-15 |
| Reducing the intensity of acid-forming function of the stomach | more than 25 | more than 15 |
Heidelberg Capsules
Heidelberg capsules are single-use radio capsules swallowed by patients who, during the passage of the patient’s gastrointestinal tract , transmit via radio signal information about the value of the acid capsule measured in the gastrointestinal lumen. The name comes from the city of Heidelberg ( Germany ). In the early 1960s, at the Department of Gastroenterology of the University of Heidelberg, Hans Nöller, with financial support from Telefunken ( German: Telefunken ; Germany), conducted at least 1000 clinical trials in adult patients using pH-metric radio capsules for three years. After that, pH capsules were called Heidelberg. [4] [5]
The first pH metric radio capsule was developed by von Ardenne and Sprung ( GDR ) [6] . Noller’s pH radio capsule appeared a few months later [7] , however, due to the fact that Neller conducted a very large number of studies with his capsule, the pH radio capsule is usually associated with the name of Nöller (more precisely, the city of Heidelberg, where Nöller conducted his research). [eight]
The first version of the "Heidelberg capsule" Nöller determined the pH in the range from 1.5 to 8 pH with an accuracy of 0.5 pH. There were two electrodes in the radio capsule: the measuring one was antimony, made in the form of a ring mounted on the capsule body and the silver chloride reference electrode - a ring-shaped silver wire coated with a layer of silver chloride and immersed in a solution of sodium chloride , electrolytically connected to the environment through a porous membrane. Due to the insufficient electrical capacity of the power source, the first samples worked for no more than 6 hours. After improving the power source, the operating time increased to 20-30 hours. The capsule had a length of 18 mm, a diameter of 8 mm, and a weight of 1 g. The operating frequency of the radio capsule generator was about 1800 kHz. [7]
About the Russian spelling of the surname of Hans Noller
The spelling “Noller” is traditional, generally accepted in Russian-language gastroenterological literature. [1] [7] [9] According to the modern approach to the translation of proper names with umlaut “ö”, the name “Nöller” should be written “Nöller”.
Bibliography
- Nöller HG Die Endoradiosondentechnik und ihre Bedeutung für die innere Medizin. - Vortr. Dtsch. Ges. innere Med. 65 Kongr., Wiesbaden, Kongresseber., 1959, 727. (German)
- Nöller HG The techniques of measuring by endoradiosonds and their adaption to pediatrics // Proc. Second, intern. Conf. on medical electronics. - Paris, 1959. - P. 24-27.
- Nöller HG Empty stomach examinations on the effect of Spasmo-Nervogastrol using the Heidelberg capsule. - Ther Ggw. 1967 Apr; 106 (4): 556-61. PMID 5621313 . (him)
See also the list of articles by H. Nöller at PubMed .
Notes
- ↑ 1 2 Zimmerman Ya. S., Budnik Yu. B. Intragastric pH-metry: new criteria that increase its information content . Russian Journal of Gastroenterology of Hepatology, Coloproctology. 1998, No. 4, p. 18-23.
- ↑ Rakitin A. B. Development of technology and a hardware-software complex for intragastric pH metering . Abstract of dissertation for the degree of candidate of technical sciences. M.: VNIIIMT, 2008.
- ↑ Rapoport S.I. et al. PH-measurement of the esophagus and stomach in diseases of the upper digestive tract / Ed. Academician of RAMS F.I. Komarov. - M.: ID MEDPRAKTIKA-M, 2005, 208 p.
- ↑ The Heidelberg pH Diagnostic System. The pH Capsule is a Self-Contained pH Measuring Device . (eng.)
- ↑ Barrie SA Heidelberg pH capsule gastric analysis Archived February 2, 2010 on Wayback Machine . In Pizzorno JE, Murray MT eds. A Textbook of Natural Medicine. JBC Publication, Seattle, WA, 1992 .
- ↑ von Ardenne M., Sprung HB Uber den verschluckbaren Intestinalsender für pH-Wert-Signalisierung. - Naturwissenschaften, 1958, 45 , 23, 564. (German)
- ↑ 1 2 3 Babsky E. B. , Sorin A. M. , Davydov S. N. Instruments for endoradiosounding. M .: Nauka, 1975, 176 p.
- ↑ The Insider's View of Stomach pH. (unavailable link) (eng.)
- ↑ Linar E. Yu. Acid-forming function of the stomach in normal and pathological conditions . - Riga: Zinante, 1968, 438 p.