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Enfluran

Enfluran - 2-chloro-1,1,2-trifluoroethyl-difluoromethyl ether.

Enfluran
Ethrane
Enflurane.svg
Enflurane-3D-balls.png
Chemical compound
IUPAC( RS ) -2-chloro-1- (difluoromethoxy) -1,1,2-trifluoroethane
Gross formulaC 3 H 2 ClF 5 O
Molar mass184.492 g / mol
Cas
PubChem
Drugbank
Classification
ATX
Pharmacokinetics
Plasma Protein Binding97%
Route of administration
inhalation
Other names
Enfluran, Etran

Synonyms: Enfluran, Etran, Ethrane.

General information

Pharmacological action: has an anesthetic, analgesic and pronounced muscle relaxant effect.

Indications for use: used for general anesthesia for short-term surgical interventions, in obstetrics - for cesarean section.

Dosage and administration: in a mixture with oxygen or in combination with nitrous oxide and oxygen using a specially calibrated anesthetic vaporizer (for induction of anesthesia - 0.5 vol.%, In the inhaled mixture - gradually increasing to 4.5 vol.%, For maintaining the surgical stage - concentration of 0.5-2.5 vol.%).

Side effect: nausea, vomiting, hypotension are possible.

Contraindications: hypotension, cardiac arrhythmias.

Release form: in bottles of 125 and 250 ml.

Application

Enfluran is used in obstetric practice (during childbirth), with interventions that do not require a shutdown of consciousness, as well as with cesarean section.

Enflurane is used (mixed with oxygen) using an anesthesia machine with a special vaporizer.

In obstetrics (at birth), they are used in a concentration of 0.25 −1 vol.%. For induction of anesthesia, they begin with a concentration of 0.5 vol.%, Gradually increasing it every few breaths to the required level, but not exceeding 4.5 vol.%. Maintenance concentrations of enfluran 0.5 - 3 vol.%. (No more than 3%). The minimum alveolar concentration is 1.68 vol.%.


Physical Properties

PropertyValue
Boiling point at 1 atm56.5 ° C
Vapor resistance at 20 ° C22.9 kPa (172 mmHg )
Blood / gas partition coefficient1.9
Oil / gas partition coefficient98
Source - https://ru.wikipedia.org/w/index.php?title=Enfluran&oldid=76631217


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Clever Geek | 2019