Neurexin-1

Neurexin-1
Available Structures
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PDB ID List
Identifiers
	, Hs.22998, PTHSL2, SCZD17, neurexin 1
External IDs
Gene ontology
Functions
Cell component
Biological process
	Sources: Amigo / QuickGO
RNA expression profile
	; ; ; ;
Orthologists
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Neurexin-1 is one of the neurexins , membrane proteins found primarily in neurons. The 1.1 Mb neurexin-1 gene, NRXN1, is, along with NRXN3, one of the largest human genes; it contains 24 exons and several splice sites. Alternative splicing is supposedly capable of generating 2,208 alpha forms and 42 beta forms of protein. ^[one]

Content

1 Pathology
2 Interactions
3 notes
4 References

Pathology

NRXN1 and related protein genes may be associated with the development of mental disorders, in particular schizophrenia . ^[2]

In 2008, NRXN1 gene violation was observed in two unrelated patients with autism spectrum disorders , however, the father of one of the patients whose genome contained the same chromosomal abnormality did not show signs of autism , which suggests a possible interaction of NRXN1 changes with other factors. ^[3]

Interactions

It has been shown that neurexin-1 (NRXN1) interacts with neurolygin-1 ( NLGN1 ). ^[4] ^[5]

Notes

↑ Rowen L., Young J., Birditt B., Kaur A., Madan A., Philipps DL, Qin S., Minx P., Wilson RK, Hood L., Graveley BR Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity (Eng.) // Genomics : journal. - 2002 .-- April ( vol. 79 , no. 4 ). - P. 587-597 . - DOI : 10.1006 / geno.2002.6734 . - PMID 11944992 .
↑ Schizophrenia Research Forum: Neurexin and Relatives Crop Up in Schizophrenia and Other Disorders (neopr.) . Date of treatment December 30, 2008. Archived March 23, 2012. Schizophrenia Research Forum .
↑ Kim HG, Kishikawa S., Higgins AW, Seong IS, Donovan DJ, Shen Y., Lally E., Weiss LA, Najm J., Kutsche K., Descartes M., Holt L., Braddock S., Troxell R ., Kaplan L., Volkmar F., Klin A., Tsatsanis K., Harris DJ, Noens I., Pauls DL, Daly MJ, MacDonald ME, Morton CC, Quade BJ, Gusella JF Disruption of neurexin 1 associated with autism spectrum disorder (English) // Am. J. Hum. Genet. : journal. - 2008 .-- January ( vol. 82 , no. 1 ). - P. 199—207 . - DOI : 10.1016 / j.ajhg.2007.09.09.011 . - PMID 18179900 .
↑ Comoletti, Davide; Flynn Robyn; Jennings Lori L; Chubykin Alexander; Matsumura Takehito; Hasegawa Hana; Südhof Thomas C; Taylor Palmer. Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta (Eng.) // J. Biol. Chem. : journal. - United States, 2003. - December ( vol. 278 , no. 50 ). - P. 50497-50505 . - ISSN 0021-9258 . - DOI : 10.1074 / jbc.M306803200 . - PMID 14522992 .
↑ Ichtchenko, K; Nguyen T; Südhof T C. Structures, alternative splicing, and neurexin binding of multiple neuroligins (Eng.) // J. Biol. Chem. : journal. - UNITED STATES, 1996 .-- February ( vol. 271 , no. 5 ). - P. 2676-2682 . - ISSN 0021-9258 . - DOI : 10.1074 / jbc.271.5.2676 . - PMID 8576240 .

Links

Genetic dependence on smoking (inaccessible link) - news report on a study linking tobacco addiction with the neurexin-1 gene

[pmid11944992-1] Rowen L., Young J., Birditt B., Kaur A., Madan A., Philipps DL, Qin S., Minx P., Wilson RK, Hood L., Graveley BR Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity (Eng.) // Genomics : journal. - 2002 .-- April ( vol. 79 , no. 4 ). - P. 587-597 . - DOI : 10.1006 / geno.2002.6734 . - PMID 11944992 .

[urlSchizophrenia_Research_Forum_NRXN1_1-2] Schizophrenia Research Forum: Neurexin and Relatives Crop Up in Schizophrenia and Other Disorders (neopr.) . Date of treatment December 30, 2008. Archived March 23, 2012. Schizophrenia Research Forum .

[pmid18179900-3] Kim HG, Kishikawa S., Higgins AW, Seong IS, Donovan DJ, Shen Y., Lally E., Weiss LA, Najm J., Kutsche K., Descartes M., Holt L., Braddock S., Troxell R ., Kaplan L., Volkmar F., Klin A., Tsatsanis K., Harris DJ, Noens I., Pauls DL, Daly MJ, MacDonald ME, Morton CC, Quade BJ, Gusella JF Disruption of neurexin 1 associated with autism spectrum disorder (English) // Am. J. Hum. Genet. : journal. - 2008 .-- January ( vol. 82 , no. 1 ). - P. 199—207 . - DOI : 10.1016 / j.ajhg.2007.09.09.011 . - PMID 18179900 .

[pmid14522992-4] Comoletti, Davide; Flynn Robyn; Jennings Lori L; Chubykin Alexander; Matsumura Takehito; Hasegawa Hana; Südhof Thomas C; Taylor Palmer. Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta (Eng.) // J. Biol. Chem. : journal. - United States, 2003. - December ( vol. 278 , no. 50 ). - P. 50497-50505 . - ISSN 0021-9258 . - DOI : 10.1074 / jbc.M306803200 . - PMID 14522992 .

[pmid8576240-5] Ichtchenko, K; Nguyen T; Südhof T C. Structures, alternative splicing, and neurexin binding of multiple neuroligins (Eng.) // J. Biol. Chem. : journal. - UNITED STATES, 1996 .-- February ( vol. 271 , no. 5 ). - P. 2676-2682 . - ISSN 0021-9258 . - DOI : 10.1074 / jbc.271.5.2676 . - PMID 8576240 .