HAR1F - RNA gene , part of the evolutionarily accelerated part of the human genome. The gene is located on the long arm of the 20th chromosome; The RNA product of the gene is expressed in Cahal-Retzius cells .
HAR1F was discovered in 2006 in a study that first demonstrated the presence of 49 areas that most distinguish humans from chimpanzees. [1] The regions were numbered according to their distance from the evolutionary ancestor, and HAR1F, along with another gene from the HAR1 region, HAR1R , has the largest structural differences, possibly leading to a number of evolutionary innovations in the structure of the human nervous system.
The functions and mechanism of action of HAR1F are poorly understood, but it is known that the gene is expressed from the 7th to the 18th week of fetal development in the dorsal part of the forebrain. In adults, the gene is active in the cerebellum, forebrain; also the gene product is found in the testes. The structural differences between the human RNA of the HAR1 region and chimpanzee RNA are investigated. [2]
Notes
- ↑ Pollard K. et al. An RNA gene expressed during cortical development evolved rapidly in humans. Advanced electronic publishing. Nature. August 16, 2006.
- ↑ Beniaminov A., Westhof E., Krol A. Distinctive structures between chimpanzee and human in a brain noncoding RNA (English) // RNA : journal. - 2008 .-- July ( vol. 14 , no. 7 ). - P. 1270-1275 . - DOI : 10.1261 / rna.1054608 . - PMID 18511501 .