Suspension ( lat. Suspensum , lat. Suspendere - weigh, suspend) is a liquid dosage form , which is a dispersed system containing one or more solid medicinal substances suspended in a liquid - water , glycerin , liquid oil, etc.
Suspensions are used for internal and external use, as well as for injection [1] .
Suspensions are prepared by the dispersion or condensation method. The preparation of suspensions by the dispersion method is carried out by the method of suspension or stirring. When suspended, the solid drug substance is ground in a mortar, first in a dry form, and then with a small amount of liquid, after which the resulting pulp is washed off with the remaining amount of liquid in a dish for vacation. When stirring, the insoluble matter is triturated with a small amount of liquid, the resulting pulp is diluted 8-10 times and after 1-2 minutes the settled suspension is poured into a dish for vacation. The procedure is repeated with the precipitate several times until the complete use of the starting material.
The condensation method of preparation is based on diluting alcohol solutions with water, aqueous - alcohol or mixing solutions of substances that mutually impair the solubility of each other.
Suspensions are characterized by aggregative and sedimentation stability. These indicators are greater, the smaller the particle size of the dispersed phase, the closer the density of the dispersed phase and the dispersion medium, and the higher the viscosity of the latter. The stability of suspensions increases with the addition of high molecular weight compounds [2] .
Literature
- Maysky V.V., Muratov V.K. Pharmacology with the formulation. - 3rd ed., Revised. and add. - M .: Medicine , 1986.- S. 38 .-- 448 p.
Notes
- β Appendix 1 to the OST Industry Standard 91500.05.001-00 βDrug Quality Standards. Key Points
- β Kulikov Yu.A., Slivkin A.I., Afanasyeva T.G. Pharmaceutical Encyclopedic Dictionary. - M .: VEDANTA, 2015 .-- S. 242. - 352 p. - ISBN 978-5-9904577-2-0 .