Sulfacetamide ( obsolete. Albucid ) is an antimicrobial bacteriostatic agent, sulfonamide . It is an intermediate product of the synthesis of streptocide .
| Sulfacetamide | |
|---|---|
| Sulfacetamide | |
 | |
| Chemical compound | |
| IUPAC | N - [(4-aminophenyl) sulfonyl] acetamide |
| Gross formula | C 8 H 10 N 2 O 3 S |
| Molar mass | 214.243 g / mol |
| Cas | |
| PubChem | |
| Drugbank | |
| Classification | |
| ATX | |
| Pharmacokinetics | |
| The half-life. | from 7 to 12.8 hours |
| Dosage Forms | |
| eye drops, ointment , solution for intravenous and intramuscular administration | |
| Other names | |
| Sulfacetamide Sodium, Sulfacyl Sodium, Sulfacyl Soluble, Sulfacil Sodium, Sulfacyl Sodium | |
Content
- 1 Pharmacological action
- 2 Dosage form: eye drops, ointment for external use
- 2.1 Pharmacokinetics
- 2.2 Indications
- 2.3 Contraindications
- 2.4 dosage
- 2.5 Side Effects
- 2.6 Special instructions
- 2.7 Interaction
- 3 Dosage form: solution for intravenous and intramuscular administration
- 3.1 Indications
- 3.2 Contraindications
- 3.3 dosage
- 3.4 Side Effects
- 3.5 Special instructions
- 4 References
Pharmacological action
Antimicrobial bacteriostatic agent, sulfonamide. The mechanism of action is due to competitive antagonism with PABA , inhibition of dihydropteroate synthetase , impaired synthesis of tetrahydrofolate acid , necessary for the synthesis of purines and pyrimidines . Active against gram-positive and gram-negative cocci , Escherichia coli , Shigella spp. , Vibrio cholerae , Clostridium perfringens , Bacillus anthracis , Corynebacterium diphtheriae , Yersinia pestis , Chlamydia spp. , Actinomyces israelii , Toxoplasma gondii .
Dosage form: eye drops, ointment for external use
Pharmacokinetics
Penetrates into the tissue and fluid of the eye . It is absorbed into the systemic circulation through the inflamed conjunctiva .
Indications
Conjunctivitis , blepharitis , purulent corneal ulcer , prevention and treatment of blennorrhea in newborns, gonorrheal and chlamydial eye diseases in adults.
Contraindications
Hypersensitivity .
Dosage
Locally, instill 1-2 drops in each conjunctival sac 4-6 times a day. For the prevention of blennorrhea in newborns, 2 drops in each conjunctival sac immediately after birth and 2 drops in 2 hours. Ointment is placed 3-4 times a day for an eyelid .
Side Effects
Burning, lacrimation, pain, itching in the eyes, allergic reactions .
Special instructions
Patients with hypersensitivity to furosemide , thiazide diuretics , sulfonylurea or carbonic anhydrase inhibitors may have an increased sensitivity to sulfacetamide.
Interaction
Joint use with procaine and tetracaine reduces the bacteriostatic effect.
Dosage form: solution for intravenous and intramuscular administration
Indications
Pneumonia , purulent tracheobronchitis , urinary tract infections .
Contraindications
Hypersensitivity, inhibition of bone marrow hematopoiesis, uremia .
Dosage
In a conjunctival sac, adults and children are instilled 1-2 drops of the drug in each conjunctival sac 4-6 times a day.
For the prevention of blennorrhea in newborns, 2 drops of the drug are instilled into each conjunctival sac immediately after birth and 2 drops after 2 hours.
Side Effects
Allergic reactions , leukopenia , nausea .
Special instructions
Patients with hypersensitivity to furosemide , thiazide diuretics , sulfonylureas or carbonic anhydrase inhibitors may have an increased sensitivity to sulfacetamide.
Links
- Albucid
- Sulfacetamide // Medicines / M.D. Mashkovsky . - Reference Mashkovsky on-line .
- Sulfacetamide (Sulfacetamide) . Encyclopedia of medicines and pharmaceutical products . Radar Patent. - Instruction, application and formula.